aman-1 encodes an ortholog of human lysosomal mannosidase (MAN2B1;OMIM:609458, mutated in alpha-mannosidosis); AMAN-1 is predicted to helpdigest glycoproteins by removing mannose residues from their N-linkedoligosaccharides; AMAN-1 has seven predicted N-glycosylation sites;AMAN-1 is biochemically active in vitro, has optimal activity at pH4-4.5, and is unaffected by Co(II); however, AMAN-1 expressed in Pichiapastoris lacks normal activity, perhaps because it requires othersubunits in vivo; aman-1 is expressed in neurons and intestine.
Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Is an ortholog of human MAN2B1 (mannosidase alpha class 2B member 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.