WormBase Tree Display for Gene: WBGene00018995
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| WBGene00018995 | SMap | S_parent | Sequence | F56H1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ccpp-1 | Person_evidence | WBPerson321 | |||||
| WBPerson11120 | |||||||||
| Sequence_name | F56H1.5 | ||||||||
| Molecular_name | F56H1.5 | ||||||||
| F56H1.5.1 | |||||||||
| CE41324 | |||||||||
| Other_name | Nnac1 | Paper_evidence | WBPaper00029379 | ||||||
| CELE_F56H1.5 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | ccpp-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 04 Jun 2010 16:03:52 | WBPerson2970 | Name_change | CGC_name | ccpp-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ccpp | ||||||||
| Allele (73) | |||||||||
| Strain | WBStrain00032218 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Contained_in_operon | CEOP1975 | ||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00017136 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ccpp-1 encodes a putative ATP/ADP-activated metallocarboxypeptidase that may function in vivo as an alpha-tubulin C-terminal tyrosine carboxypeptidase; CCPP-1 is orthologous to murine AGTPBP-1/Nna1/pcd (upregulated in damaged mouse spinal cord and mutated in Purkinje cell degeneration) and human AGTPBP1 (OMIM:606830); murine AGTPBP-1 is genetically required for tubulin carboxypeptidase activity in vivo, and CCPP-1's nearest paralog CCPP-6 has biochemical traits consistent with tubulin carboxypeptidase activity; CCPP-1 and its mammalian AGTPBP1 orthologs, along with other proteins, comprise a M14D3 peptidase subfamily. | Paper_evidence | WBPaper00029056 | |||||
| WBPaper00029378 | |||||||||
| WBPaper00029379 | |||||||||
| WBPaper00029380 | |||||||||
| WBPaper00029381 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 01 Jul 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Involved in egg-laying behavior. Predicted to be located in cilium; dendrite; and perikaryon. Expressed in ciliated neurons and gubernacular muscle. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Is an ortholog of human AGBL1 (AGBL carboxypeptidase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11555 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:26504) | ||||
| Molecular_info | Corresponding_CDS | F56H1.5 | |||||||
| Corresponding_CDS_history | F56H1.5:wp178 | ||||||||
| Corresponding_transcript | F56H1.5.1 | ||||||||
| Other_sequence (37) | |||||||||
| Associated_feature | WBsf219475 | ||||||||
| WBsf219476 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00048770 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003824 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116548 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00078338 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9653 | ||||||||
| Expr1018158 | |||||||||
| Expr1038198 | |||||||||
| Expr1152519 | |||||||||
| Expr2009766 | |||||||||
| Expr2028006 | |||||||||
| Drives_construct | WBCnstr00009452 | ||||||||
| WBCnstr00009453 | |||||||||
| WBCnstr00026140 | |||||||||
| Construct_product | WBCnstr00009452 | ||||||||
| WBCnstr00009453 | |||||||||
| WBCnstr00009457 | |||||||||
| WBCnstr00026140 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (13) | |||||||||
| Map_info | Map | I | Position | 0.442013 | Error | 0.000959 | |||
| Positive | Positive_clone | F56H1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
