WormBase Tree Display for Gene: WBGene00020035
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| WBGene00020035 | SMap | S_parent | Sequence | R12E2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | egg-5 | Person_evidence | WBPerson597 | |||||
| Sequence_name | R12E2.10 | ||||||||
| Molecular_name | R12E2.10 | ||||||||
| R12E2.10.1 | |||||||||
| CE18142 | |||||||||
| Other_name | CELE_R12E2.10 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | egg-5 | ||||||||
| DB_info | Database | AceView | gene | 1E738 | |||||
| WormQTL | gene | WBGene00020035 | |||||||
| WormFlux | gene | WBGene00020035 | |||||||
| NDB | locus_tag | CELE_R12E2.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00020035|UniProtKB=O61789 | |||||||
| family | PTHR19134 | ||||||||
| NCBI | gene | 172007 | |||||||
| RefSeq | protein | NM_058915.9 | |||||||
| SwissProt | UniProtAcc | O61789 | |||||||
| TREEFAM | TREEFAM_ID | TF316265 | |||||||
| UniProt_GCRP | UniProtAcc | O61789 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 10 Sep 2007 09:53:41 | WBPerson2970 | Name_change | CGC_name | egg-5 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | egg | ||||||||
| Allele (39) | |||||||||
| Strain | WBStrain00036488 | ||||||||
| WBStrain00000056 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (65) | |||||||||
| Structured_description | Concise_description | egg-5 encodes a pseudotyrosine phosphatase; egg-5, along with egg-4 which also encodes a pseudotyrosine phosphatase, are required for the egg-to-oocyte transition and embryonic development; EGG-4 and EGG-5 function to negatively regulate the activity of the MBK-2 DYRK family kinase by sequestering MBK-2 at the oocyte cortex and, in the case of EGG-4, by inhibiting its enzymatic activity; EGG-5 physically interacts with MBK-2; EGG-5 localizes to the oocyte cortex and nuclei. | Paper_evidence | WBPaper00035426 | |||||
| WBPaper00035427 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Mar 2011 00:00:00 | ||||||||
| Automated_description | Enables protein kinase binding activity. Involved in cortical actin cytoskeleton organization; female gamete generation; and positive regulation of protein localization to cell cortex. Located in cell cortex and nucleus. Expressed in oocyte. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Is an ortholog of human PTPRG (protein tyrosine phosphatase receptor type G) and PTPRZ1 (protein tyrosine phosphatase receptor type Z1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9685) | ||||
| Molecular_info | Corresponding_CDS | R12E2.10 | |||||||
| Corresponding_transcript | R12E2.10.1 | ||||||||
| Other_sequence (27) | |||||||||
| Associated_feature | WBsf980999 | ||||||||
| WBsf219248 | |||||||||
| WBsf219249 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram1230 | ||||||||
| Expr8837 | |||||||||
| Expr8938 | |||||||||
| Expr1021046 | |||||||||
| Expr1038706 | |||||||||
| Expr1155506 | |||||||||
| Expr2011203 | |||||||||
| Expr2029439 | |||||||||
| Drives_construct | WBCnstr00025414 | ||||||||
| Construct_product | WBCnstr00013631 | ||||||||
| WBCnstr00025414 | |||||||||
| Antibody | WBAntibody00002049 | ||||||||
| WBAntibody00002060 | |||||||||
| Microarray_results | SMD_R12E2.10 | ||||||||
| A_12_P119777 | |||||||||
| Aff_R12E2.10 | |||||||||
| GPL13394_WBGene00020035 | |||||||||
| GPL13914_R12E2.10 | |||||||||
| GPL3518_CE18142 | |||||||||
| GPL8673_R12E2_10P01329 | |||||||||
| GPL9450_R12E2.10 | |||||||||
| cea2.d.35603 | |||||||||
| cea2.d.35604 | |||||||||
| Expression_cluster (177) | |||||||||
| Interaction (280) | |||||||||
| Map_info | Map | I | Position | -1.65231 | Error | 0.00328 | |||
| Positive | Positive_clone | R12E2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
