WormBase Tree Display for Gene: WBGene00020100
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| WBGene00020100 | SMap | S_parent | Sequence | R148 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | mks-1 | Paper_evidence | WBPaper00032899 | |||||
| Person_evidence | WBPerson2136 | ||||||||
| WBPerson641 | |||||||||
| Sequence_name | R148.1 | ||||||||
| Molecular_name | R148.1 | ||||||||
| R148.1.1 | |||||||||
| CE54054 | |||||||||
| Other_name | xbx-7 | ||||||||
| CELE_R148.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | mks-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00020100 | |||||
| WormFlux | gene | WBGene00020100 | |||||||
| NDB | locus_tag | CELE_R148.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00020100|UniProtKB=O17269 | |||||||
| family | PTHR12968 | ||||||||
| NCBI | gene | 187903 | |||||||
| RefSeq | protein | NM_001381800.1 | |||||||
| TrEMBL | UniProtAcc | A0A679L8Q5 | |||||||
| UniProt_GCRP | UniProtAcc | A0A679L8Q5 | |||||||
| OMIM | gene | 609883 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 01 Apr 2005 11:05:24 | WBPerson2970 | Name_change | CGC_name | xbx-7 | ||||
| 3 | 19 Oct 2009 17:02:44 | WBPerson9133 | Name_change | CGC_name | mks-1 | ||||
| 4 | 20 Jan 2020 14:57:15 | WBPerson4025 | Event | Split_into | WBGene00305998 | ||||
| Split_into | WBGene00305998 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mks | ||||||||
| Allele (107) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00019364 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00021416 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mks-1 encodes, by alternative splicing, two isoforms of an ortholog of human MKS1, and is paralogous to MKRS-1 and MKRS-2; MKS-1 is redundantly required with NPH-4 for roughly normal foraging, and with both NPH-1 and NPH-4 for cilia formation; MKS-1 is expressed in a subset of amphid and inner labial neurons, in a DAF-19-dependent manner; MKS-1 forms a complex with MKRS-1 and MKRS-2 at the base of cilia, requires MKRS-1 and MKRS-2 for localization to the transistion zone, and is coexpressed with these proteins in ciliated sensory neurons; mks-1(RNAi) suppresses the normal egg-laying defect of egl-9 mutants. | Paper_evidence | WBPaper00025051 | |||||
| WBPaper00031596 | |||||||||
| WBPaper00032899 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Oct 2009 00:00:00 | ||||||||
| Automated_description | Expressed in neurons. Used to study Meckel syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 13; Joubert syndrome 28; and Meckel syndrome 1. Is predicted to encode a protein with the following domains: B9-type C2 domain and Ciliary basal body-associated, B9 protein. Is an ortholog of human MKS1 (MKS transition zone complex subunit 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050778 | |||||||
| DOID:0060340 | |||||||||
| Potential_model | DOID:0110135 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7121) | |||||
| DOID:0070115 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7121) | ||||||
| DOID:0110997 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7121) | ||||||
| DOID:1935 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7121) | ||||||
| Models_disease_asserted | WBDOannot00000032 | ||||||||
| WBDOannot00000303 | |||||||||
| Molecular_info | Corresponding_CDS | R148.1 | |||||||
| Corresponding_CDS_history | R148.1:wp171 | ||||||||
| R148.1:wp178 | |||||||||
| R148.1:wp275 | |||||||||
| R148.1b:wp275 | |||||||||
| Corresponding_transcript | R148.1.1 | ||||||||
| Other_sequence | JI482919.1 | ||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00070831 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00051965 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070830 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017864 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00007463 | ||||||||
| WBCnstr00007464 | |||||||||
| WBCnstr00011418 | |||||||||
| WBCnstr00013349 | |||||||||
| WBCnstr00013915 | |||||||||
| WBCnstr00022911 | |||||||||
| Construct_product | WBCnstr00013349 | ||||||||
| WBCnstr00022911 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (133) | |||||||||
| Interaction (11) | |||||||||
| Map_info | Map | III | Position | -7.44322 | Error | 0.012355 | |||
| Positive | Positive_clone | R148 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
