WormBase Tree Display for Gene: WBGene00020114
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| WBGene00020114 | SMap | S_parent | Sequence | R153 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pde-4 | Person_evidence | WBPerson433 | |||||
| Sequence_name | R153.1 | ||||||||
| Molecular_name (25) | |||||||||
| Other_name | CELE_R153.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | pde-4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 10 Dec 2004 15:16:09 | WBPerson2970 | Name_change | CGC_name | pde-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pde | ||||||||
| Allele (400) | |||||||||
| Strain | WBStrain00023484 | ||||||||
| WBStrain00031931 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00008443 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00011146 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00011433 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016328 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022389 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pde-4 encodes a cAMP phosphodiesterase orthologous to Drosophila dunce and the mammalian PDE4 family of phosphodiesterases; genetic analysis indicates that pde-4 activity is required for negative regulation of cAMP pools in the synaptic signaling network that controls locomotory rates and for regulation of sleep-like behavior (lethargus) during larval development; antibody staining of adult animals detects PDE-4 throughout the nervous system, where it localizes to non-active zone areas of synapses. | Paper_evidence | WBPaper00027337 | |||||
| WBPaper00031383 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 06 Nov 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and sleep. Located in synapse. Expressed in DD neuron and VD neuron. Human ortholog(s) of this gene implicated in acrodysostosis. Is an ortholog of human PDE4B (phosphodiesterase 4B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:14669 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8783) | ||||
| DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8781) | ||||||
| Molecular_info | Corresponding_CDS | R153.1a | |||||||
| R153.1b | |||||||||
| R153.1c | |||||||||
| R153.1d | |||||||||
| R153.1e | |||||||||
| R153.1f | |||||||||
| R153.1g | |||||||||
| R153.1h | |||||||||
| Corresponding_transcript | R153.1a.1 | ||||||||
| R153.1b.1 | |||||||||
| R153.1c.1 | |||||||||
| R153.1d.1 | |||||||||
| R153.1e.1 | |||||||||
| R153.1e.2 | |||||||||
| R153.1f.1 | |||||||||
| R153.1g.1 | |||||||||
| R153.1h.1 | |||||||||
| Other_sequence (55) | |||||||||
| Associated_feature (50) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00051985 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00022429 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001406 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051984 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034944 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017874 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr14481 | ||||||||
| Expr1028931 | |||||||||
| Expr1038750 | |||||||||
| Expr1155626 | |||||||||
| Expr2014797 | |||||||||
| Expr2033031 | |||||||||
| Drives_construct | WBCnstr00040904 | ||||||||
| Construct_product | WBCnstr00000260 | ||||||||
| WBCnstr00000261 | |||||||||
| WBCnstr00007396 | |||||||||
| WBCnstr00007402 | |||||||||
| WBCnstr00022699 | |||||||||
| Antibody | WBAntibody00001082 | ||||||||
| WBAntibody00001083 | |||||||||
| Microarray_results (65) | |||||||||
| Expression_cluster (169) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | II | Position | 0.5076 | |||||
| Positive | Positive_clone | R153 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (24) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
