WormBase Tree Display for Gene: WBGene00021237
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| WBGene00021237 | SMap | S_parent | Sequence | Y20F4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | crtc-1 | Person_evidence | WBPerson5137 | |||||
| WBPerson917 | |||||||||
| Sequence_name | Y20F4.2 | ||||||||
| Molecular_name | Y20F4.2 | ||||||||
| Y20F4.2.1 | |||||||||
| CE47164 | |||||||||
| Other_name | CELE_Y20F4.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | crtc-1 | ||||||||
| DB_info | Database | AceView | gene | 1C601 | |||||
| WormQTL | gene | WBGene00021237 | |||||||
| WormFlux | gene | WBGene00021237 | |||||||
| NDB | locus_tag | CELE_Y20F4.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00021237|UniProtKB=Q95XA8 | |||||||
| family | PTHR13589 | ||||||||
| NCBI | gene | 259368 | |||||||
| RefSeq | protein | NM_058516.8 | |||||||
| SwissProt | UniProtAcc | Q95XA8 | |||||||
| TREEFAM | TREEFAM_ID | TF318544 | |||||||
| UniProt_GCRP | UniProtAcc | Q95XA8 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:04 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 30 Nov 2010 13:55:01 | WBPerson2970 | Name_change | CGC_name | crtc-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | crtc | ||||||||
| Allele (222) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (32) | |||||||||
| Structured_description | Concise_description | crtc-1 encodes a CREB-regulated transcriptional coactivator orthologous to mammalian CRTCs (OMIM: 608972); CRTC-1 is a central node linking the upstream lifespan modifiers AMPK and calcineurin to CREB activity via a shared signal-transduction pathway; posttranslational modification of CRTC-1 is required for their effects on longevity; CRTC-1 is both a critical and direct target of aak-2-mediated longevity; the longevity effects of inactivating crtc-1 are mediated by crh-1; crtc-1 is expressed throughout the intestine of the worm, as well as in head and tail neurons. | Paper_evidence | WBPaper00038172 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 25 Jul 2011 00:00:00 | ||||||||
| Automated_description | Enables cAMP response element binding protein binding activity. Involved in determination of adult lifespan. Located in cytosol and nucleus. Expressed in RICL; RICR; head neurons; intestine; and tail neurons. Is an ortholog of human CRTC1 (CREB regulated transcription coactivator 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y20F4.2 | |||||||
| Corresponding_CDS_history | Y20F4.2:wp115 | ||||||||
| Y20F4.2:wp230 | |||||||||
| Corresponding_transcript | Y20F4.2.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature | WBsf643075 | ||||||||
| WBsf655729 | |||||||||
| WBsf982788 | |||||||||
| WBsf982789 | |||||||||
| WBsf982790 | |||||||||
| WBsf1009281 | |||||||||
| WBsf1009282 | |||||||||
| WBsf217269 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00055654 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00055658 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9323 | ||||||||
| Expr12275 | |||||||||
| Expr1010914 | |||||||||
| Expr1039256 | |||||||||
| Expr1159180 | |||||||||
| Expr2010545 | |||||||||
| Expr2028785 | |||||||||
| Drives_construct (14) | |||||||||
| Construct_product (16) | |||||||||
| Regulate_expr_cluster | WBPaper00046499:AMPK_regulated | ||||||||
| WBPaper00066163:crtc-1(wbm18)_downregulated_N2 | |||||||||
| WBPaper00066163:crtc-1(wbm18)_downregulated_set-2(ok952) | |||||||||
| WBPaper00066163:crtc-1(wbm18)_upregulated_N2 | |||||||||
| WBPaper00066163:crtc-1(wbm18)_upregulated_set-2(ok952) | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (102) | |||||||||
| Interaction | WBInteraction000504757 | ||||||||
| WBInteraction000504758 | |||||||||
| WBInteraction000504759 | |||||||||
| WBInteraction000527116 | |||||||||
| WBInteraction000527404 | |||||||||
| WBInteraction000538773 | |||||||||
| WBInteraction000538804 | |||||||||
| WBInteraction000556135 | |||||||||
| Map_info | Map | I | Position | -12.3005 | Error | 0.031538 | |||
| Positive | Positive_clone | Y20F4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
