WormBase Tree Display for Gene: WBGene00224334

WBGene00224334 SMap: S_parent: Sequence: Bm_v4_Chr3_scaffold_001
  Identity: Version: 1
    Name: Sequence_name: Bm4073
      Molecular_name: Bm4073
        Bm4073.1
        BM07497
      Other_name: TAG4073 Curator_confirmed: WBPerson4055
        Bm1_07880A Curator_confirmed: WBPerson4055
        Bm1_07895A Curator_confirmed: WBPerson4055
        Bm1_07895 Person_evidence: WBPerson5841
      Public_name: Bm4073
    Species: Brugia malayi
    History: Version_change: 1 10 Dec 2012 14:43:24 WBPerson4055 Event: Created
    Status: Live
  Gene_info: Biotype: SO:0001217
    RNASeq_FPKM: WBls:0000097 5.67981 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000097.L3/L4.WBbt:0007833.SRP068692.SRX1539819
        0.114936 From_analysis: RNASeq.brugia.WBls:0000097.control_median
        0.229871 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000097.Unknown.WBbt:0007833.SRP068692.SRX2505171
        12.2268 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000097.Unknown.WBbt:0007833.SRP068692.SRX2505769
        0 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000097.Unknown.WBbt:0007833.SRP068692.SRX1539876
            RNASeq.brugia.WBStrain00041073.WBls:0000097.Unknown.WBbt:0007833.SRP068692.SRX1539886
            RNASeq.brugia.WBStrain00041073.WBls:0000097.Unknown.WBbt:0007833.SRP068692.SRX2505170
        3.14904 From_analysis: RNASeq.brugia.WBls:0000097.control_mean
        6.43757 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000097.Unknown.WBbt:0007833.SRP068692.SRX1539817
      WBls:0000078 13.275 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000078.Unknown.WBbt:0007833.SRP068692.SRX1539874
        4.45908 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000078.Unknown.WBbt:0007833.SRP068692.SRX2415911
        4.74744 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000078.Unknown.WBbt:0007833.SRP068692.SRX1539873
        5.04836 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000078.Unknown.WBbt:0007833.SRP068692.SRX2415908
        5.23317 From_analysis: RNASeq.brugia.WBls:0000078.control_median
            RNASeq.brugia.WBStrain00041073.WBls:0000078.Unknown.WBbt:0007833.SRP068692.SRX2415910
        5.28606 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000078.Unknown.WBbt:0007833.SRP068692.SRX2415909
        6.81479 From_analysis: RNASeq.brugia.WBls:0000078.control_mean
        9.65442 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000078.Unknown.WBbt:0007833.SRP068692.SRX1539875
      WBls:0000080 10.4025 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000080.Unknown.WBbt:0007833.SRP068692.SRX2505771
        13.1416 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000080.Unknown.WBbt:0007833.SRP068692.SRX2505770
        3.00032 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000080.Unknown.WBbt:0007833.SRP068692.SRX1539947
        6.45161 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000080.Unknown.WBbt:0007833.SRP068692.SRX1539949
        8.24901 From_analysis: RNASeq.brugia.WBls:0000080.control_mean
        8.42706 From_analysis: RNASeq.brugia.WBls:0000080.control_median
      WBls:0000081 10.0389 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX1539813
        10.2712 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX1539758
        10.9586 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2505953
        11.0142 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX1539799
        11.1415 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Male.WBbt:0007833.SRP068692.SRX1539865
        12.2898 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.male.WBbt:0007833.SRP068692.SRX1539862
        13.532 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.ERP000948.ERX026030
        0 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.ERP000948.ERX026028
            RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP090644.SRX2200121
        2.5864 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX1539952
        2.67811 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2414981
        3.72455 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2414982
        4.23303 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP090644.SRX2200122
        4.48354 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2409230
        5.28245 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2409229
        6.10856 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2416293
        6.31474 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2416292
        6.97411 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX1539954
        7.10481 From_analysis: RNASeq.brugia.WBls:0000081.control_mean
        7.46229 From_analysis: RNASeq.brugia.WBls:0000081.control_median
            RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2505954
        7.70475 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2505955
        8.02023 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2415043
        9.26995 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX1539755
        9.32171 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000081.Unknown.WBbt:0007833.SRP068692.SRX2415044
      WBls:0000082 10.2539 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000082.female.WBbt:0007833.SRP068692.SRX1539871
        0 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000082.Unknown.WBbt:0007833.ERP000948.ERX026033
            RNASeq.brugia.WBStrain00041073.WBls:0000082.Unknown.WBbt:0007833.ERP000948.ERX026039
        2.27619 From_analysis: RNASeq.brugia.WBls:0000082.control_median
            RNASeq.brugia.WBStrain00041073.WBls:0000082.Unknown.WBbt:0007833.ERP000948.ERX026041
        4.09211 From_analysis: RNASeq.brugia.WBls:0000082.control_mean
        7.93048 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000082.Female.WBbt:0007833.SRP068692.SRX1539869
      WBls:0000083 0.892644 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.ERP000948.ERX026036
        10.2947 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447472
        10.9416 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447448
        11.2721 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447469
        12.3867 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.male.WBbt:0007833.SRP090644.SRX2200124
        12.5608 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447444
        12.8668 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447450
        13.0673 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176953
        13.0991 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP068692.SRX1539085
        13.1894 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447465
        14.6378 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Male.WBbt:0007833.ERP000948.ERX026029
        1.47385 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.female.WBbt:0007833.SRP090644.SRX2200125
        15.4502 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447454
        16.0245 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176955
        16.4234 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176954
        16.9204 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447442
        17.243 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176969
        17.3589 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447471
        1.77945 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.male.WBbt:0007833.SRP090644.SRX2200127
        17.8637 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Male.WBbt:0007833.SRP068692.SRX1539740
        17.982 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447467
        18.0009 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447457
        18.2763 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447453
        18.2772 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176963
        19.6431 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Male.WBbt:0007833.SRP068692.SRX1539737
        19.9484 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176951
        0 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.ERP000948.ERX026032
            RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.ERP000948.ERX026037
            RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447459
            RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447466
            RNASeq.brugia.WBStrain00041073.WBls:0000083.male.WBbt:0007833.SRP090644.SRX2200119
            RNASeq.brugia.WBStrain00041073.WBls:0000083.male.WBbt:0007833.SRP090644.SRX2200120
        20.1779 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176961
        20.6125 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.male.WBbt:0007833.SRP090644.SRX2200123
        21.2295 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447470
        21.3009 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447463
        23.03 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447441
        2.5668 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.male.WBbt:0007833.SRP090644.SRX2200128
        25.7647 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176948
        26.155 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176962
        26.1817 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176952
        26.4912 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447468
        26.6082 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176957
        26.7013 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447447
        26.992 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176964
        27.7082 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176966
        27.8768 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447455
        28.3691 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176956
        28.4378 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176950
        28.939 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176968
        29.5954 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447456
        30.6749 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176958
        31.1888 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447452
        31.6279 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447458
        32.7365 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176960
        34.6639 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176970
        3.4906 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447443
        35.1297 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447440
        37.6169 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447446
        37.7174 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176949
        38.1382 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176959
        40.5462 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447464
        40.7694 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176967
        4.29241 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.female.WBbt:0007833.SRP090644.SRX2200118
        49.7712 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176947
        57.0363 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447461
        6.07477 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.female.WBbt:0007833.SRP090644.SRX2200117
        6.32606 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447445
        6.63387 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.female.WBbt:0007833.SRP090644.SRX2200129
        6.73357 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447449
        6.75011 From_analysis: RNASeq.brugia.WBls:0000083.control_median
        6.86636 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.female.WBbt:0007833.SRP090644.SRX2200130
        69.7908 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447462
        7.46641 From_analysis: RNASeq.brugia.WBls:0000083.control_mean
        7.87197 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.female.WBbt:0007833.SRP090644.SRX2200126
        8.21788 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447460
        8.79394 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP063061.SRX1176965
        9.08649 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP068692.SRX1539734
        9.09394 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.female.WBbt:0007833.SRP068692.SRX1539730
        9.38559 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP068692.SRX1539707
        9.49575 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066610.SRX1447451
        9.75551 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000083.Female.WBbt:0007833.SRP066611.SRX1447473
      WBls:0000092 7.4497 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000092.Unknown.WBbt:0007833.SRP068692.SRX1539751
        7.48154 From_analysis: RNASeq.brugia.WBls:0000092.control_mean
            RNASeq.brugia.WBls:0000092.control_median
        7.51339 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000092.Unknown.WBbt:0007833.SRP068692.SRX1539746
      WBls:0000094 1.75172 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000094.Male.WBbt:0007833.ERP000948.ERX026035
        1.80504 From_analysis: RNASeq.brugia.WBls:0000094.control_mean
            RNASeq.brugia.WBls:0000094.control_median
        1.85836 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000094.Male.WBbt:0007833.ERP000948.ERX026034
      WBls:0000101 6.43757 From_analysis: RNASeq.brugia.total_over_all_stages.control_median
        6.53765 From_analysis: RNASeq.brugia.total_over_all_stages.control_mean
      WBls:0000662 11.5068 From_analysis: RNASeq.brugia.WBls:0000662.control_mean
            RNASeq.brugia.WBls:0000662.control_median
        14.1667 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000662.Unknown.WBbt:0007833.ERP000948.ERX026031
        8.84689 From_analysis: RNASeq.brugia.WBStrain00041073.WBls:0000662.Unknown.WBbt:0007833.ERP000948.ERX026040
      WBls:0000663 1.01077 From_analysis: RNASeq.brugia.WBls:0000663.control_mean
            RNASeq.brugia.WBls:0000663.control_median
            RNASeq.brugia.WBStrain00041073.WBls:0000663.Unknown.WBbt:0007833.ERP000948.ERX026038
    Contained_in_operon: BMOP2217
    Ortholog: CSP21.g2195 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP38.g3624 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      Cang_2012_03_13_00019.g1226 Caenorhabditis angaria From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05608 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g4964 Panagrellus redivivus From_analysis: WormBase-Compara
      WBGene00248599 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00304576 Pristionchus pacificus From_analysis: WormBase-Compara
    Structured_description: Automated_description: Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: Transmembrane protein 170 and Putative transmembrane protein 170. Is an ortholog of O. volvulus OVOC11790. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Bm4073
    Corresponding_transcript: Bm4073.1
    Other_sequence: JI168926.1
      JO470097.1
  Experimental_info: Expression_cluster: WBPaper00049974:ivermectin_100nM_48h_downregulated
      WBPaper00051007:downregulated_M120_vs_M30
      WBPaper00051007:downregulated_M120_vs_M42
      WBPaper00051007:upregulated_M120_vs_F120
  Reference: WBPaper00045439
  Method: Gene