WormBase Tree Display for Interaction: WBInteraction000518831
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| WBInteraction000518831 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00022880 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr9042 | ||||
| Transgene | WBTransgene00006294 | ||||
| Construct | WBCnstr00006148 | ||||
| WBGene00000424 | Interactor_type | Trans_regulator | |||
| WBGene00000426 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00090672 | Interactor_type | Trans_regulator | ||
| WBVar00253079 | Interactor_type | Trans_regulator | |||
| Interaction_summary | The normal punctate endosomal distribution of GFP-TBC-2 was disrupted in animals lacking CED-10 or CED-12. The intensity of GFP-TBC-2 endosomal labeling was reduced by 6 to 7-fold in ced-10 and ced-12 mutants. These results indicate that CED-10 and CED-12 are required in vivo for the efficient recruitment of TBC-2 to endosomal membranes, likely through direct binding of CED-10(GTP) to TBC-2. | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [tbc-2::gfp] | ||||
| Transgene | |||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Subcellular_localization | endosome | ||
| Paper | WBPaper00041307 |
