WormBase Tree Display for Interaction: WBInteraction000523933
expand all nodes | collapse all nodes | view schema
| WBInteraction000523933 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00003741 | Interactor_type | Effector | |
| WBGene00006765 | Interactor_type | Affected | |||
| WBGene00006774 | Interactor_type | Affected | |||
| WBGene00002974 | Interactor_type | Affected | |||
| Interaction_summary | This RNAi was able to suppress the locomotion phenotypes found in L-AChR(gf) animals. L-AChR(gf) enhances synaptic activation of muscles by increasing L-AChR function. | ||||
| Throughput | Low_throughput | ||||
| Interaction_RNAi | WBRNAi00101913 | ||||
| Interaction_phenotype | WBPhenotype:0000643 | ||||
| WBProcess | WBbiopr:00000004 | ||||
| Paper | WBPaper00045671 | ||||
| Remark | The authors wanted to enhance synaptic activation of muscles by increasing L-AChR function, thus they introduced an amino acid change at a highly conserved position in the pore-lining M2 regions of cDNAs encoding the UNC-29, UNC-38 and LEV-1 subunits. They constructed a strain (ufIs6) stably expressing the unc-29(L/S), unc-38(V/S) and lev-1(L/S) cDNAs under control of the muscle-specific myo-3 promoter, and refer to this as L-AChR(gf). |
