WormBase Tree Display for Interaction: WBInteraction000541862
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| WBInteraction000541862 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00000912 | Interactor_type | Trans_regulator | |
| WBGene00004932 | Interactor_type | Trans_regulated | |||
| Interaction_summary | "We used transcriptional reporters of two DAF-16/FOXO-regulated genes, sod-3 and ins-7, to examine DAF-16/FOXO-dependent transcriptional activation and repression, respectively[6,20]. Expression of the Psod-3::GFP reporter is induced under conditions of low insulin-like signalling, for example, in daf-2 mutants[18]. Further inactivation by RNAi of DAF-16/FOXO or of the SWI/SNF core subunits SWSN-4 and SWSN-1 and the BAF-subclass signature subunit SWSN-8 suppressed this induction of Psod-3::GFP (Fig. 2a,b)." | ||||
| Detection_method | Reporter_gene | [sod-3p::gfp] | |||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000067 | ||
| Paper | WBPaper00042296 | ||||
| Remark | Fig. 2ab |
