WormBase Tree Display for Interaction: WBInteraction000542516
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| WBInteraction000542516 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00006959 | Interactor_type | Trans_regulated | |
| Molecule_interactor | WBMol:00003571 | Interactor_type | Trans_regulator | ||
| Interaction_summary | "Inositol requiring enzyme-1 (IRE-1) is an ER membrane kinase/endonuclease that catalyzes the splicing and subsequent activation of the transcription factor X box binding protein-1 (XBP-1) in response to ER stress. If the UPR is activated, the ratio of spliced to total xbp-1 mRNA should increase. To further assess UPR activation, then we quantified the amount of spliced and total xbp-1 mRNA. As shown in Fig. 4B, spliced xbp-1 mRNA levels did not change significantly (P < 0.3) in worms exposed to 200 mM NaCl. In 400 mM NaCl-treated animals, the ratio decreased significantly (P 0.001; Fig. 4B)." | ||||
| Detection_method | RT_PCR | ||||
| Regulation_level | Post_transcriptional | ||||
| Paper | WBPaper00041657 | ||||
| Remark | Fig. 4b |
