WormBase Tree Display for Interaction: WBInteraction000557935
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WBInteraction000557935 | Interaction_type | Regulatory | Change_of_localization | |
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Interactor (2) | ||||
Interaction_summary | "We tested whether ANC-1 localized properly in a collection of unc-84 mutant backgrounds. ANC-1 failed to localize to the nuclear periphery in the null unc-84 allele and in alleles that have missense mutations in or near the conserved SUN (for Sad1p, UNC-84 homology) domain of UNC-84 and that disrupt both nuclear migration and anchorage (6) (Fig. 2E). In contrast, ANC-1 was detected at the nuclear envelope in unc-84 alleles that have missense mutations or small deletions in the NH2-terminus of UNC-84 and that disrupt only migration (6) (Fig. 2F). ANC-1 was still detected at normal levels in the cytoplasm in all unc-84 mutants." | |||
Detection_method | Antibody | |||
Regulation_level | Post_translational | |||
Regulation_result | Positive_regulate | Life_stage | WBls:0000041 | |
Subcellular_localization | nuclear envelope | |||
Paper | WBPaper00005468 | |||
Remark | Fig. 2e |