WormBase Tree Display for Interaction: WBInteraction000576752
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| WBInteraction000576752 | Interaction_type | Genetic | Partial_suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Sub_suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00022172 | Interactor_type | Effector | |
| Transgene | WBTransgene00014904 | ||||
| WBGene00001872 | Interactor_type | Affected | |||
| Variation_interactor | WBVar00088021 | Interactor_type | Affected | ||
| Interaction_summary | "...we found that the presence of meIs8, a transgene insertion expressing a functional GFP::COSA-1 fusion protein (Yokoo et al. 2012), resulted in significant rescue of the CO deficit caused by the him-14(it44ts) mutation at 20C , a semi-permissive temperature at which MutSgamma activity is reduced but not eliminated." "In contrast to the high frequency of univalents observed in him-14(it44ts) mutant oocytes at the semi-permissive temperature of 20C, six bivalents (indicative of successful CO formation for all homolog pairs) were observed in most meIs8 him-14(it44ts) oocytes at 20C." " However, suppression of the him-14(it44ts) CO defect does not occur at the more restrictive temperatures of 24 or 25C where activity of MutSgamma is severely impaired, indicating that the presence of meIs8 does not bypass the requirement for MutSgamma activity to form COs." | ||||
| Detection_method | Transgene | ||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0001814 | ||||
| WBProcess | WBbiopr:00000099 | ||||
| Paper | WBPaper00061682 |
