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WBPicture0000007717 Description: Figure 3. PKD-2::GFP localization is altered in unc-101, lov-1 and IFT mutants. (A,D,G,J) Cartoons of a sensory neuron expressing PKD-2::GFP (shown in green) for each genotype. (B,E,H,K) CEMs, (C,F,I,L) RnBs and HOB neurons. (A-C) Wild-type localization of PKD-2::GFP. PKD-2 in ciliary endings (ciliary membrane and ciliary base, arrowheads) in CEMs and RnBs. (D-F) In unc-101(m1) mutants, PKD-2::GFP is uniformly distributed throughout neurons, including axons, cell bodies, dendrites (thick arrows) and cilia (arrowhead). (G-I) In lov-1(sy582) mutants, PKD-2::GFP aggregates within the cell bodies (arrows) and is expressed in a lower level in ray cilia (arrowhead in 3I). The boxed inset in I shows a closer view of a ray cell body containing PKD-2::GFP aggregates. (J-L) In daf-10(p821) mutants, PKD-2::GFP accumulates in the ciliary base (arrowheads). In the RnBs, PKD-2::GFP also mislocalizes to dendrites (thick arrow). This mutant phenotype is consistent in other IFT single and double mutant backgrounds. Scale bars: 10 μm.
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  Acknowledgment: Template: WormBase thanks <Journal_URL> for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Reprinted from <Article_URL>. Copyright (<Publication_year>) with permission from <Publisher_URL>.
    Publication_year: 2006
    Article_URL: DOI id 10.1242/dev.02555
    Journal_URL: Development
    Publisher_URL: TheCompanyofBiologists
  Reference: WBPaper00028448