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| WBPicture0000010682 | Description | Fig. 1. Structure and expression of zig genes. (A) Schematic structure of the predicted ZIG proteins. Protein domain, signal sequence (SS), transmembrane (TM), and GPI-anchor- predictions were performed as described in Web fig. 1 and based on PCR-amplified cDNAs. ZIG proteins are solely defined by the presence of exclusively two Ig domains (hence "zig" for "zwei Ig"); otherwise the ZIG proteins are highly divergent among themselves both in primary sequence (Web fig. 2) and exon/intron organization [panel (B)], suggesting anancient origin of this gene family. Database searches reveal that other metazoan genomes also contain a variety of secreted and transmembrane 2-Ig domain-only proteins whose role in neural development has not been explored (Web fig. 1B). (B) Structure of zig-promoter::gfp fusion constructs and summary of expression patterns (21). (C) Transgenic animals expressing zig::gfp fusion constructs. Arrows in insets point to PVT (21). (D) Temporal dynamics of zig-4::gfp expression from the integrated array otIs20. Note the absence of zig-4::gfp expression in PVT at embryonic and early L1 stages (upper left panel). Similar temporal expression profiles in PVT are observed with chromosomally integrated zig-1, zig-2, zig-3, and zig-8::gfp reporter genes. zig-5::gfp expression can first be observed at late (>threefold) stages of embryonic development. (E) Timeline of zig gene expression in relation to C. elegans development, timing of pioneer axon outgrowth (1) and unc-6/netrin expression (3). Expression of zig genes in PVT persists in adults, yet becomes less penetrant. | |||
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| Acknowledgment | Template | From <Article_URL>. Reprinted with permission from <Publisher_URL>. Readers may view, browse, and/or download material for temporary copying purposes only, provided these uses are for noncommercial personal purposes. Except as provided by law, this material may not be further reproduced, distributed, transmitted, modified, adapted, performed, displayed, published, or sold in whole or in part, without prior written permission from the publisher. | |||
| Publication_year | 2002 | ||||
| Article_URL | DOI | id | 10.1126/science.1066642 | ||
| Journal_URL | Science | ||||
| Publisher_URL | AAAS | ||||
| Reference | WBPaper00005064 |
