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WBPicture0000011158DescriptionFigure 4. UNC-7 localizes to perisynaptic regions along the dorsal nerve cord and the expression of UNC-7 in neurons is required for active zone differentiation. Specific UNC-7 antibody staining in nervous system (A), dorsal nerve cord (B), ventral nerve cord (C), and muscle (D; M, muscle; dc, dorsal cord). UNC-7 staining shows small discrete puncta, as well as to larger puncta occurring periodically along nerve cords (arrowheads). E, Staining of UNC-7 shows discrete puncta along the dorsal cord in the muscle. F-J, Coimmunostaining of UNC-7 (red) with presynaptic proteins (green) UNC-10 (F-F'), SYD-2 (G-G'), synaptic GFP markers UNC-49::GFP (H-H'), SYD-2::GFP (I-I'), and SNB-1::GFP (J-J'). K-K', Live imaging of GFP::UNC-7 (green) and SNB-1::mRFP (red) in GABAergic neurons. Scale bar, 5 um. L, An illustration of UNC-7 protein localization in neurons and muscles.
NameF4.large.jpg
DepictExpr_patternExpr8588
AnatomyWBbt:0003675
WBbt:0003679
WBbt:0005829
WBbt:0006750
Cellular_componentGO:0045202
AcknowledgmentTemplateWormBase thanks <Journal_URL> for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Reprinted from <Article_URL>. Copyright (<Publication_year>) with permission from <Publisher_URL>.
Publication_year2009
Article_URLDOIid10.1523/JNEUROSCI.0637-09.2009
Journal_URLTheJournalofNeuroscience
Publisher_URLSocietyofNeuroscience
ReferenceWBPaper00033075