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WBPicture0000015212DescriptionFigure 1. Mitochondrial function of roller and dumpy C elegans:A) Representative images of WT, dumpy, and roller C. elegans 48 hours after plating L1s. B) Mean mitochondrial DNA copy number across strains. C) Mean nuclear DNA copy number across strains. D) Mean mitochondrial: nuclear DNA copy number (CN) ratio across strains. E) Mean basal respiration across strains. F) Mean mitochondrial respiration across strains. G) Mean non-mitochondrial respiration across strains. H) Mean maximal respiration across strains. I) Mean proton leak across strains. J) Mean spare capacity across strains. K) Mean ATP content across strains. L) Mean worm volume across strains. In all figures, the x-axis represents worm strain. For Figures B-C, copy number is shown on the y-axis. For Figures E-J, OCR in pmol/min, normalized to the appropriate normalization unit, is displayed on the y-axis. Gray bars represent data normalized to worm count. Blue bars represent data normalized to mtDNA CN/106. For Figure K, pmol of ATP, normalized to microgram of protein, is shown on the y-axis. For Figure L, volume in picoliters is displayed on the y-axis. Statistical significance was determined using a one-way ANOVA with a Tukey post hoc test for multiple comparisons (*: p<0.05, **: p<0.01). For Figures E-J, statistical testing was conducted within each normalization method but not between methods. For all graphs, error bars represent the standard error of the mean (SEM).
Namec59ba907e8921277cc4659b9912e198a.jpg
AcknowledgmentTemplateReprinted from <Journal_URL>
Publication_year2023
Article_URLDOIid10.17912/micropub.biology.000798
Journal_URLmicroPublicationBiology
Publisher_URLMicropublication
ReferenceWBPaper00065364