WormBase Tree Display for RNAi: WBRNAi00110069
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| WBRNAi00110069 | Homol | Homol_homol | T24H7:RNAi | ||
|---|---|---|---|---|---|
| Sequence_info | PCR_product | sjj_T24H7.1 | |||
| Experiment | Genotype | age-1(hx546) | |||
| Delivered_by | Bacterial_feeding | ||||
| Inhibits | Predicted_gene | T24H7.1 | Inferred_automatically | RNAi_primary | |
| Gene | WBGene00004015 | Inferred_automatically | RNAi_primary | ||
| Transcript | T24H7.1.1 | Inferred_automatically | RNAi_primary | ||
| Species | Caenorhabditis elegans | ||||
| Reference | WBPaper00045812 | ||||
| Phenotype_not_observed | WBPhenotype:0000039 | Remark | "Specifically we investigated the interaction with age-1, akt-1, akt-2 and sgk-1 encoding kinases. Intriguingly, we uncovered that phb-1 and phb-2 RNAi resulted in lifespan extension only in the sgk-1(ok538) mutant background (Figure 1A and Table S1), recapitulating the phenotype observed in daf-2 mutants... However, prohibitin depletion did not extend the lifespan of akt-1(ok525) (as already published [12]), akt-2(ok393) and age-1(hx546) loss of function mutant worms (Figures S1A, S1B, S1D and Table S1)." | ||
| Remark | (Table S1, Figure S1D) phb-2 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation. | ||||
| Method | RNAi |
