WormBase Tree Display for RNAi: WBRNAi00114745
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| WBRNAi00114745 | Homol | Homol_homol | Y119D3B:RNAi | ||
|---|---|---|---|---|---|
| Sequence_info | PCR_product | mv_G_YK3216 | |||
| Experiment | Genotype | drIs34[myo-3p::(PR)50-GFP; myo-3p::mCherry] | |||
| Delivered_by | Bacterial_feeding | ||||
| Inhibits | Predicted_gene | Y119D3B.15 | Inferred_automatically | RNAi_primary | |
| Gene | WBGene00022492 | Inferred_automatically | RNAi_primary | ||
| Transcript | Y119D3B.15.1 | Inferred_automatically | RNAi_primary | ||
| Y119D3B.15.2 | Inferred_automatically | RNAi_primary | |||
| Species | Caenorhabditis elegans | ||||
| Reference | WBPaper00059748 | ||||
| Phenotype_not_observed | WBPhenotype:0000679 | Remark | "Therefore, dss-1(RNAi) could suppress (PR)50 toxicity either because it prevents (PR)50 localization to the nucleus or because it inhibits relevant toxicity pathways downstream of nuclear (PR)50. To distinguish between these possibilities, we used fluorescence microscopy to determine if (PR)50-GFP localization is altered by dss-1(RNAi) (Figure 1I). In dss-1(RNAi) animals, PR nuclear localization was unaffected. Therefore, dss-1 is not required for PR nuclear localization but rather facilitates the (PR)50 toxicity mechanism(s)." | ||
| Remark | dss-1 (WBGene00022492) RNAi, ORFeome clone | ||||
| Method | RNAi |
