WormBase Tree Display for Strain: WBStrain00047321
expand all nodes | collapse all nodes | view schema
| WBStrain00047321 | Status | Live | ||
|---|---|---|---|---|
| Genotype | glp-1(q35)/eT1 III; him-5(e1490)/eT1 V. | |||
| Public_name | JK590 | |||
| Contains | Gene | WBGene00001609 | ||
| WBGene00001864 | ||||
| Variation | WBVar00144039 | |||
| WBVar00240990 | ||||
| Rearrangement | eT1 | |||
| Properties | Outcrossed | x? | ||
| Mutagen | EMS | |||
| CGC_received | 31 Oct 2019 00:00:00 | |||
| Location | CGC | |||
| Made_by | WBPerson320 | |||
| Remark | Heterozygotes are wild-type and segregate wild-type heterozygotes, glp-1(q35) homozygotes (Muv steriles), eT1 homozygotes (Unc-36), and males. glp-1(q35) has a semi-dominant multi-vulva phenotype as well as the loss-of-function Glp phenotype (sterility and embryonic lethality). The q35 mutation is a nonsense mutation that eliminates 122 C-terminal amino acids including a PEST sequence. The C terminus was thought to contain a negative regulatory domain that inactivates glp-1 in the VPCs; the inappropriate glp-1(q35) activity can substitute for lin-12 vulval fate determination. References: Austin J & Kimble J. Cell. 1987 Nov 20;51(4):589-99. Mango S, et al. Nature. 1991 Aug 29;352(6338):811-5. | Inferred_automatically | From CGC strain data | |
| Species | Caenorhabditis elegans |
