WormBase Tree Display for Transgene: WBTransgene00005741
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| WBTransgene00005741 | Public_name | WBPaper00032271Ex1 | ||||||
|---|---|---|---|---|---|---|---|---|
| Summary | [unc-18::unc-18cDNA(D214N)] | |||||||
| Construction | Construct | WBCnstr00005614 | ||||||
| Genetic_information | Extrachromosomal | |||||||
| Phenotype | WBPhenotype:0001481 | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Thrashing frequency increased | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_gene | WBGene00006757 | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Genotype | unc-18(e81) | Paper_evidence | WBPaper00032271 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0001612 | Paper_evidence | WBPaper00032271 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Transgenic animals with the D214N UNC-18 mutation completely lost any ethanol-induced hyperactivity | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_gene | WBGene00006757 | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Treatment | 0-100mM EtOH | Paper_evidence | WBPaper00032271 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| Genotype | unc-18(e81) | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0001613 | Paper_evidence | WBPaper00032271 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | The ability of ethanol to depress activity was significantly decreased for transgenic worms expressing the UNC-18 D214N mutation | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_gene | WBGene00006757 | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Treatment | 100-500mM of EtOH | Paper_evidence | WBPaper00032271 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| Genotype | unc-18(e81) | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0004023 | Paper_evidence | WBPaper00032271 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | D214N mutants moved slightly faster (20%) than the wild-type | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_gene | WBGene00006757 | Paper_evidence | WBPaper00032271 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_assay | Genotype | unc-18(e81) | Paper_evidence | WBPaper00032271 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| Phenotype_not_observed (6) | ||||||||
| Reference | WBPaper00032271 | |||||||
| Species | Caenorhabditis elegans |
