WormBase Tree Display for Transgene: WBTransgene00009236

WBTransgene00009236 Public_name: mfIs57
  Summary: [Cel-egl-20(+); Cel-pmyo-2::GFP]
  Construction: Construct: WBCnstr00008922
    Coinjection_other: Cel-pmyo-2::GFP
    Integration_method: Gamma_irradiation
  Construction_summary: Integration of mfEx59 by gamma-ray irradiation of JU1763. Outcrossed 6 times to AF16.
  Genetic_information: Integrated
    Phenotype: WBPhenotype:0000345 Paper_evidence: WBPaper00040050
        Curator_confirmed: WBPerson712
        Remark: Overexpression of this Wnt resulted in a significant increase in P3.p division frequency. Paper_evidence: WBPaper00040050
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00001188 Paper_evidence: WBPaper00040050
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0008112 PATO:0000460 Paper_evidence: WBPaper00040050
                Curator_confirmed: WBPerson712
      WBPhenotype:0001400 Paper_evidence: WBPaper00040050
        Curator_confirmed: WBPerson712
        Remark: The LIN-39 protein profile significantly differed between the egl-20 overexpressing strain and AF16. Paper_evidence: WBPaper00040050
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00001188 Paper_evidence: WBPaper00040050
            Curator_confirmed: WBPerson712
      WBPhenotype:0002017 Paper_evidence: WBPaper00040050
        Curator_confirmed: WBPerson712
        Remark: Cel-egl-20(+) overexpression in C. briggsae AF16 resulted in an increased P4.p competence to levels similar to P8.p, mimicking the C. elegans N2 situation. egl-20 overexpression in C. briggsae AF16 also allowed P3.p to regulate to a vulval fate in some individuals. Paper_evidence: WBPaper00040050
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00001188 Paper_evidence: WBPaper00040050
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0008112 PATO:0000460 Paper_evidence: WBPaper00040050
                Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000436 Paper_evidence: WBPaper00040050
        Curator_confirmed: WBPerson712
        Remark: The LIN_39 protein profile appeared overall slightly flatter in the Cel-egl-20(+) overexpressing strain, yet the peak position was not displaced on P5.p as in C. elegans. Paper_evidence: WBPaper00040050
            Curator_confirmed: WBPerson712
        Caused_by_gene: WBGene00001188 Paper_evidence: WBPaper00040050
            Curator_confirmed: WBPerson712
  Associated_with: Strain: WBStrain00043679
  Reference: WBPaper00040050
  Species: Caenorhabditis elegans