WormBase Tree Display for Transgene: WBTransgene00016353
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WBTransgene00016353 | Public_name | dvIs50 | ||||||
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Summary | [pCL45 (Psnb-1::Abeta 1-42::3' UTR(long) + Pmtl-2::GFP] | |||||||
Synonym | [pCL45 (Psnb-1::Abeta 1-42::3' UTR(long); Pmtl-2::GFP] | |||||||
Construction | Construct | WBCnstr00015907 | ||||||
Coinjection_other | mlt-2::GFP | |||||||
Genetic_information | Integrated | |||||||
Map | I | |||||||
Phenotype | WBPhenotype:0001785 | Paper_evidence | WBPaper00056229 | |||||
Curator_confirmed | WBPerson27070 | |||||||
Remark | reduced memory due to impaired mitophagy | Paper_evidence | WBPaper00056229 | |||||
Curator_confirmed | WBPerson27070 | |||||||
Caused_by_other | human amyloid Beta (Aβ) | Paper_evidence | WBPaper00056229 | |||||
Curator_confirmed | WBPerson27070 | |||||||
Phenotype_assay | Treatment | Transgenic C. elegans (CL2355) containing human A and the control strain (CL2122) containing an empty vector were generated in laboratory of Dr. Chris Link (University of Colorado, Denver, CO). The CL2355 strain [smg-1ts (snb-1/A1-42/long 3'-UTR) employs the promoter of C. elegans synaptobrevin ortholog (snb-1) to drive pan-neuronal expression of A1-42, which is inducible by temperature up-shift to 23C. | Paper_evidence | WBPaper00056229 | ||||
Curator_confirmed | WBPerson27070 | |||||||
WBPhenotype:0002573 | Paper_evidence | WBPaper00056229 | ||||||
Curator_confirmed | WBPerson27070 | |||||||
Remark | reduced memory due to impaired mitophagy | Paper_evidence | WBPaper00056229 | |||||
Curator_confirmed | WBPerson27070 | |||||||
Caused_by_other | human amyloid Beta (Aβ) | Paper_evidence | WBPaper00056229 | |||||
Curator_confirmed | WBPerson27070 | |||||||
Phenotype_assay | Treatment | Transgenic C. elegans (CL2355) containing human A and the control strain (CL2122) containing an empty vector were generated in laboratory of Dr. Chris Link (University of Colorado, Denver, CO). The CL2355 strain [smg-1ts (snb-1/A1-42/long 3'-UTR) employs the promoter of C. elegans synaptobrevin ortholog (snb-1) to drive pan-neuronal expression of A1-42, which is inducible by temperature up-shift to 23C. | Paper_evidence | WBPaper00056229 | ||||
Curator_confirmed | WBPerson27070 | |||||||
Associated_with | Strain | WBStrain00005106 | ||||||
Reference (17) | ||||||||
Species | Caenorhabditis elegans |