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WormBase Tree Display for Transgene: WBTransgene00016353

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Name Class

WBTransgene00016353Public_namedvIs50
Summary[pCL45 (Psnb-1::Abeta 1-42::3' UTR(long) + Pmtl-2::GFP]
Synonym[pCL45 (Psnb-1::Abeta 1-42::3' UTR(long); Pmtl-2::GFP]
ConstructionConstructWBCnstr00015907
Coinjection_othermlt-2::GFP
Genetic_informationIntegrated
MapI
PhenotypeWBPhenotype:0001785Paper_evidenceWBPaper00056229
Curator_confirmedWBPerson27070
Remarkreduced memory due to impaired mitophagyPaper_evidenceWBPaper00056229
Curator_confirmedWBPerson27070
Caused_by_otherhuman amyloid Beta (Aβ)Paper_evidenceWBPaper00056229
Curator_confirmedWBPerson27070
Phenotype_assayTreatmentTransgenic C. elegans (CL2355) containing human A and the control strain (CL2122) containing an empty vector were generated in laboratory of Dr. Chris Link (University of Colorado, Denver, CO). The CL2355 strain [smg-1ts (snb-1/A1-42/long 3'-UTR) employs the promoter of C. elegans synaptobrevin ortholog (snb-1) to drive pan-neuronal expression of A1-42, which is inducible by temperature up-shift to 23C.Paper_evidenceWBPaper00056229
Curator_confirmedWBPerson27070
WBPhenotype:0002573Paper_evidenceWBPaper00056229
Curator_confirmedWBPerson27070
Remarkreduced memory due to impaired mitophagyPaper_evidenceWBPaper00056229
Curator_confirmedWBPerson27070
Caused_by_otherhuman amyloid Beta (Aβ)Paper_evidenceWBPaper00056229
Curator_confirmedWBPerson27070
Phenotype_assayTreatmentTransgenic C. elegans (CL2355) containing human A and the control strain (CL2122) containing an empty vector were generated in laboratory of Dr. Chris Link (University of Colorado, Denver, CO). The CL2355 strain [smg-1ts (snb-1/A1-42/long 3'-UTR) employs the promoter of C. elegans synaptobrevin ortholog (snb-1) to drive pan-neuronal expression of A1-42, which is inducible by temperature up-shift to 23C.Paper_evidenceWBPaper00056229
Curator_confirmedWBPerson27070
Associated_withStrainWBStrain00005106
Reference (17)
SpeciesCaenorhabditis elegans