WormBase Tree Display for Transgene: WBTransgene00018938
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WBTransgene00018938 | Genetic_information | Phenotype | WBPhenotype:0000006 | Paper_evidence | WBPaper00006537 | |||
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Curator_confirmed | WBPerson712 | |||||||
Remark | The transgenic animals (GFP-positive) with over expressed CeCHIP were egg-laying defective (Egl) at adult stage at 20 deg C. These animals could lay few eggs but huge eggs remained inside the uterus and ultimately many eggs hatched in the uterus. | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_gene | WBGene00000500 | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000062 | Paper_evidence | WBPaper00006537 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | 100% of the transgenic (CHN-1 overexpressing) embryos remained unhatched, whereas 95% of the control transgenic (GFP-positive) embryos hatched. Reduced chn-1 DNA concentrations (to 25.0 ng/ul) resulted in 95% of the CHIP transgenic (GFP-positive) embryos hatching. | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_gene | WBGene00000500 | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000308 | Paper_evidence | WBPaper00006537 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Although most of the transgenic F1 progeny grew with Unc and Egl phenotypes, about 30% of the F1 remained in the L1/L2 stage when grown at 25 deg C. arrested animals with 1% SDS and found that they are resistant to SDS. These data indicate that these arrested larvae are dauers . | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Penetrance | Incomplete | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_gene | WBGene00000500 | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Temperature_sensitive | Heat_sensitive | 25 | Paper_evidence | WBPaper00006537 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000408 | Paper_evidence | WBPaper00006537 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | When shifted from 25 to 15 deg C, these dauers did not return to a normal life cycle; CHIP transgenic animals form irreversible dauers at 25 deg C. The other 70% of the transgenic animals grew into adults. | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Penetrance | Incomplete | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_gene | WBGene00000500 | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Temperature_sensitive | Heat_sensitive | 25 | Paper_evidence | WBPaper00006537 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000643 | Paper_evidence | WBPaper00006537 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | DNA injected at a concentration of 25.0 ng/ul, where 95% of the transgenic embryos hatched, resulted in all transgenic animals (GFP-positive) being uncoordinated in locomotion (Unc) from the larval stage. | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_gene | WBGene00000500 | Paper_evidence | WBPaper00006537 | |||||
Curator_confirmed | WBPerson712 | |||||||
Reference | WBPaper00006537 |