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WormBase Tree Display for Transgene: WBTransgene00022864

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Name Class

WBTransgene00022864Public_namegcIs41
Summary[Prab3::m-nonN-Nmnat1::mCherry]
ConstructionConstructWBCnstr00022611
Integration_methodUV
Genetic_informationIntegrated
PhenotypeWBPhenotype:0001236Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Remark"Surprisingly, in the absence of EtBr, both neuro- and ub-m-nonN-Nmnat1 mildly but significantly increased the basal level of activation of Phsp-6::GFP, and neuro-m-nonN-Nmnat1 increased Phsp-60::GFP (Figures 4c and d)."Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
"Consistent with the latter hypothesis, taxol dose dependently reduced the basal expression of the Phsp-6::GFP mitoUPR reporter and this reduction of the expression of the mitoUPR reporter was blocked by neuronal m-nonN-Nmnat1 (Figures 5e and f)."Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Caused_by_otherm-nonN-Nmnat1Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Phenotype_assayGenotypezcIs13 [Phsp-6::GFP]Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
zcIs9 [Phsp-60::GFP]Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
WBPhenotype:0001278Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Remark"Consistent with amelioration of mitochondrial folding stress rather than other effects of EtBr on mitochondria such as suppressing transcription, neuro-m-nonN-Nmnat1 significantly reduced the induction by EtBr of the mitoUPR transcriptional reporter, Phsp-6::GFP(zcIs13) (Figure 4b)."Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Caused_by_otherm-nonN-Nmnat1Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Phenotype_assayGenotypezcIs13 [Phsp-6::GFP]Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
WBPhenotype:0001384Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
RemarkSupplementary Table S1Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Caused_by_otherm-nonN-Nmnat1Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
WBPhenotype:0001990Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Remark"Given the primarily neuronal phenotype in mouse, we asked whether m-nonN-Nmnat1 expression in neurons alone (neuro-m-nonNNmnat1)is sufficient to protect the organism from hypoxia and found that neuronal expression did indeed provide strong protection (Figure 2b)."Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Caused_by_otherm-nonN-Nmnat1Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
EQ_annotationsGO_termGO:0001666PATO:0000460Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000039Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
RemarkSupplementary Table S1Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
Caused_by_otherm-nonN-Nmnat1Paper_evidenceWBPaper00049307
Curator_confirmedWBPerson2987
ReferenceWBPaper00049307
SpeciesCaenorhabditis elegans