WormBase Tree Display for Transgene: WBTransgene00022864
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WBTransgene00022864 | Public_name | gcIs41 | |||||||
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Summary | [Prab3::m-nonN-Nmnat1::mCherry] | ||||||||
Construction | Construct | WBCnstr00022611 | |||||||
Integration_method | UV | ||||||||
Genetic_information | Integrated | ||||||||
Phenotype | WBPhenotype:0001236 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Surprisingly, in the absence of EtBr, both neuro- and ub-m-nonN-Nmnat1 mildly but significantly increased the basal level of activation of Phsp-6::GFP, and neuro-m-nonN-Nmnat1 increased Phsp-60::GFP (Figures 4c and d)." | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
"Consistent with the latter hypothesis, taxol dose dependently reduced the basal expression of the Phsp-6::GFP mitoUPR reporter and this reduction of the expression of the mitoUPR reporter was blocked by neuronal m-nonN-Nmnat1 (Figures 5e and f)." | Paper_evidence | WBPaper00049307 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Caused_by_other | m-nonN-Nmnat1 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Genotype | zcIs13 [Phsp-6::GFP] | Paper_evidence | WBPaper00049307 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
zcIs9 [Phsp-60::GFP] | Paper_evidence | WBPaper00049307 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001278 | Paper_evidence | WBPaper00049307 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Consistent with amelioration of mitochondrial folding stress rather than other effects of EtBr on mitochondria such as suppressing transcription, neuro-m-nonN-Nmnat1 significantly reduced the induction by EtBr of the mitoUPR transcriptional reporter, Phsp-6::GFP(zcIs13) (Figure 4b)." | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Caused_by_other | m-nonN-Nmnat1 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Genotype | zcIs13 [Phsp-6::GFP] | Paper_evidence | WBPaper00049307 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001384 | Paper_evidence | WBPaper00049307 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | Supplementary Table S1 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Caused_by_other | m-nonN-Nmnat1 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001990 | Paper_evidence | WBPaper00049307 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Given the primarily neuronal phenotype in mouse, we asked whether m-nonN-Nmnat1 expression in neurons alone (neuro-m-nonNNmnat1)is sufficient to protect the organism from hypoxia and found that neuronal expression did indeed provide strong protection (Figure 2b)." | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Caused_by_other | m-nonN-Nmnat1 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | GO_term | GO:0001666 | PATO:0000460 | Paper_evidence | WBPaper00049307 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_not_observed | WBPhenotype:0000039 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | Supplementary Table S1 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Caused_by_other | m-nonN-Nmnat1 | Paper_evidence | WBPaper00049307 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Reference | WBPaper00049307 | ||||||||
Species | Caenorhabditis elegans |