WormBase Tree Display for Expr_pattern: Expr11675
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| Expr11675 | Expression_of | Gene | WBGene00000390 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00000390 | |||
| Expression_data | Anatomy_term | WBbt:0005741 | Certain | |
| WBbt:0006748 | Certain | |||
| WBbt:0006749 | Certain | |||
| GO_term | GO:0005911 | |||
| GO:0005938 | ||||
| GO:0030670 | ||||
| Subcellular_localization | In 2-cell to 32-cell embryos, CDC-42 mainly localized to cortexes at cell-cell contacts. At late stages of embryonic development, we also observed a widespread CDC-42 expression in neuronal tissues such as the nerve ring, supporting the involvement of CDC-42 in neuronal processes. During larval development and in adults, CDC-42 localized to cortexes in all cells, for example, in the vulva and in the tail. | |||
| Previous work has shown that CED-1 and CED-6 in engulfing cells are selectively recruited to the plasma membrane surrounding apoptotic cells, generating a 'halo' pattern around the corpses. A similar accumulation of GFP::CDC-42 was observed around apoptotic cell corpses during all developmental stages. Importantly, CDC-42 was significantly enriched at membranes surrounding apoptotic cell corpses compared with cortical basal as well as background levels. | ||||
| Type | Reporter_gene | |||
| Reference | WBPaper00045004 | |||
| Transgene | WBTransgene00019772 |
