WormBase Tree Display for Expr_pattern: Expr15142
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| Expr15142 | Expression_of | Gene | WBGene00014208 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00014208 | |||
| Expression_data | Anatomy_term | WBbt:0004421 | Certain | |
| WBbt:0005784 | Certain | |||
| WBbt:0006873 | Certain | |||
| WBbt:0006874 | Certain | |||
| WBbt:0006875 | Certain | |||
| GO_term | GO:0043186 | |||
| GO:0048471 | ||||
| Type | Genome_editing | |||
| Reporter_gene | ||||
| Pattern | We observed GFP::ZNFX-1 expression in the adult germline as well as in developing germ cells during all stages of embryonic and larval development. No GFP::ZNFX-1 expression was observed in somatic tissues. After fertilization, C. elegans zygotes undergo a series of asymmetric cell divisions in which germline determinants segregate with germline blastomeres. During embryonic development, ZNFX-1 foci were concentrated in, and segregated with, the germline blastomeres. In adult germ cells, GFP::ZNFX-1 was concentrated in foci that were distributed in a perinuclear pattern around nuclei. We conclude that znfx-1 encodes a germline-expressed protein that segregates with the germline and localizes to perinuclear foci in adult germ cells.GFP::ZNFX-1 and GFP::WAGO-4 colocalized with PGL-1::TagRFP in P1-P3 germline blastomeres, suggesting that ZNFX-1 and WAGO-4 are P granule factors. | |||
| Reference | WBPaper00054525 | |||
| Variation | WBVar02153223 |
