WormBase Tree Display for Expr_pattern: Expr16009

Expr16009 Expression_of: Gene: WBGene00020712
    Reflects_endogenous_expression_of: WBGene00020712
  Expression_data: Anatomy_term (32)
  Type: Reporter_gene
  Pattern: We found that ckr-1 is broadly expressed in the nervous system, showing expression in a subset of ventral nerve cord motor neurons, amphid and phasmid sensory neurons, premotor interneurons, and motor neurons in the nerve ring. We identified many of these neurons, largely from analysis of ckr-1 co-expression with previously characterized reporters. In the ventral nerve cord, we found that ckr-1 is expressed in cholinergic, but not GABAergic, ventral cord motor neurons. Amongst head neurons, the ckr-1 reporter is expressed in GABAergic RMEV, RMED, AVL and RIS neurons, cholinergic SMDV, SMDD, and RIV head motor neurons, the interneuron RIG, the serotonergic NSM neuron, and in the interneurons AIA and AIB. Additional studies using DiI uptake indicated that ckr-1 is also expressed in the amphid sensory neurons ASK and ASI and the phasmid sensory neurons PHA and PHB. With the exception of the ventral cord cholinergic neurons, the ckr-1 reporter almost exclusively labeled neurons that do not receive direct synaptic input from DVA, suggesting that NLP-12 acts at least partially through extrasynaptic mechanisms.
  Reference: WBPaper00062141
  Transgene: WBTransgene00032814