WormBase Tree Display for Expr_pattern: Expr2556
expand all nodes | collapse all nodes | view schema
| Expr2556 | Expression_of | Gene | WBGene00000837 |
|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00000837 | ||
| Expression_data | Life_stage | WBls:0000024 | |
| WBls:0000003 | |||
| WBls:0000038 | |||
| WBls:0000027 | |||
| WBls:0000035 | |||
| WBls:0000041 | |||
| Anatomy_term (17) | |||
| GO_term | GO:0005634 | ||
| GO:0005737 | |||
| Subcellular_localization | Mainly nuclear with some cytoplasmic staining. | ||
| Type | Antibody | Rabbit polyclonal antibody against full-length CUL-2 recombinant protein. | |
| Pattern | In adults, CUL-2 is observed in the germ line, with higher levels in meiotic cells. The highest CUL-2 levels are found in oocytes, where CUL-2 is mainly nuclear with some cytoplasmic staining. Similar to cul-2 mRNA, CUL-2 protein is provided to embryos as maternal product and the level decreases during embryogenesis. During larval development, CUL-2 is found in the following proliferating tissues: P cells during the L1 stage; seam cells when they divide at every molt; vulval and somatic gonad cells in late L3 and L4 stages; and intestinal cells throughout larval development. | ||
| Remark | Disruption of cul-2 expression by double-stranded RNA-mediated interference (RNAi) severely reduces the levels of both nuclear and cytoplasmic anti-CUL-2 staining. | ||
| Reference | WBPaper00003829 | ||
| Antibody_info | WBAntibody00000257 |
