WormBase Tree Display for Expr_pattern: Expr2860
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| Expr2860 | Expression_of | Gene | WBGene00006845 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00006845 | |||
| Expression_data | Anatomy_term | WBbt:0005751 | Certain | |
| WBbt:0005813 | Certain | |||
| GO_term | GO:0045202 | |||
| GO:0031594 | ||||
| Subcellular_localization | Antibody staining against the vesicular acetylcholine transporters UNC-17 and epitope-tagged acetylcholine receptors (UNC-29 and UNC-38) showed that UNC-122 clusters precisely oppose UNC-17 clusters, consistent with the localization of UNC-122 to muscle endplates. UNC-122 clusters do not precisely overlap but rather interdigitate with clusters of UNC-38 AChR or UNC-29; the relatively large size of muscle endplates suggests that UNC-122 and UNC-38 may localize to distinct subdomains within muscle end-plates. Together with the demonstration of a muscular focus of action of unc-122, authors conclude from these localization experiments that UNC-122 localizes to the postsynaptic side of NMJs. | |||
| Epitope-tagged UNC-122 shows a punctate localization along the ventral nerve cord (VNC). These sites do not coincide with muscle-hypodermis attachment sites, as observed by antibody costaining against an attachment marker protein. | ||||
| Type | Reporter_gene | |||
| Pattern | Expression of UNC-122 was observed in body wall muscle and coelomocytes. | |||
| Reference | WBPaper00006427 | |||
| Transgene | WBTransgene00001608 |
