WormBase Tree Display for Expr_pattern: Expr4213
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| Expr4213 | Expression_of | Gene | WBGene00009717 |
|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00009717 | ||
| Expression_data | Anatomy_term (15) | ||
| Subcellular_localization | Most of the DEP-1::GFP fusion protein is localized in intracellular punctae that partially colocalize with intracellular LET-23 EGFR. | ||
| Type | Reporter_gene | ||
| Pattern | Both reporters are expressed at the time of vulval induction at equal levels in P5.p, P6.p, and P7.p. After the first round of cell divisions, the translational DEP-1::GFP reporter is down-regulated in the primary lineage, but expression persists in the secondary vulval cells until the L4 stage. DEP-1::GFP expression is lower in P6.p than in P5.p or P7.p descendants in 82% of L3 and in 95% of L4 larvae (n = 26 and n = 21, respectively). A similar reduction of the expression in the primary lineage is observed with the transcriptional reporter, although the down-regulation in the primary lineage only becomes apparent at the Pn.pxx stage. dep-1p::gfp expression is lower in P6.p than in P5.p or P7.p descendants in 80% of the L3 larvae (n = 78). In most cases (e.g., 17 out of 18 larvae at the Pn.px and Pn.pxx stages), DEP-1::GFP expression is low or absent in cells expressing high LET-23 EGFR levels and vice versa. | ||
| Picture | WBPicture0000008479 | ||
| Remark | No GO_term assigned. | ||
| Reference | WBPaper00025197 | ||
| Transgene | WBTransgene00029045 |
