WormBase Tree Display for Expr_pattern: Expr9162
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| Expr9162 | Expression_of | Gene | WBGene00002174 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00002174 | |||
| Expression_data | Life_stage | WBls:0000024 | ||
| WBls:0000003 | ||||
| WBls:0000038 | ||||
| WBls:0000027 | ||||
| WBls:0000035 | ||||
| WBls:0000041 | ||||
| Anatomy_term | WBbt:0005772 | Certain | ||
| GO_term | GO:0005911 | |||
| GO:0005912 | ||||
| GO:0016323 | ||||
| Subcellular_localization | ITX-1 defines a lateral membrane domain basal to the apical junction. However, ITX-1 staining along the apical junction appears as a wider belt differently than the typical AJM/DLG pattern. Moreover, ITX-1 localization is independent of AJM-1, as ajm-1 null mutant embryos show normal ITX-1 staining. Co-labeling of ITX-1 with anti beta-G Spectrin show that it co-localizes with ITX-1 along the entire lateral membrane of gut epithelia. | |||
| Type | Antibody | |||
| Pattern | Whole mount antibody staining established the expression of the protein at the baso-lateral membranes of gut epithelia in embryonic and post-embryonic stages. Its expression was restricted to gut and was not observed in other polarized epithelia, such as the pharynx or post-embryonic vulva, uterus, and hypodermis. Immunoelectron microscopy experiments confirmed localization of ITX-1 to intestinal adherens junctions. | |||
| Picture | WBPicture0000012011 | |||
| Remark | Picture: Fig. 5A to 5C. | |||
| Reference | WBPaper00037763 | |||
| Antibody_info | WBAntibody00002166 |
