WormBase Tree Display for GO_term: GO:0034098
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| GO:0034098 | Name | VCP-NPL4-UFD1 AAA ATPase complex | |
|---|---|---|---|
| Definition | A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). | ||
| Synonym | Exact | p97-Ufd1-Npl4 complex | |
| Narrow | Cdc48p-Npl4p-Ufd1p AAA ATPase complex | ||
| Status | Valid | ||
| Type | Cellular_component | ||
| Parent | Instance_of | GO:0098796 | |
| GO:0140534 | |||
| Component_of | GO:0005789 | ||
| Attributes_of | Index | Ancestor (19) | |
| GO_annotation (11) | |||
| Version | Gene Ontology releases/2023-11-15 |
