WormBase Tree Display for Gene: HGNC:11138
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| HGNC:11138 | Identity | Name | CGC_name | Snca | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name (17) | ||||||
| Public_name | Snca | |||||
| DB_info | Database | HGNC | id | 11138 | ||
| AGR | cURI | HGNC:11138 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000145335 | ||||
| UniProt | UniProt_AC | P37840 | ||||
| OMIM | gene | 163890 | ||||
| DO | id (14) | |||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Structured_description | Automated_description | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] | Inferred_automatically | AGR_import | ||
| Experimental_info | Regulate_expr_cluster | WBPaper00061613:human-alpha-Synuclein(A53T)_downregulated | ||||
| WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated | ||||||
| WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated | ||||||
| WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated |
