WormBase Tree Display for Analysis: Microarray_Study.WBPaper00031477.ce.mr

Microarray_Study.WBPaper00031477.ce.mr DB_info: Database: GEO GSE9993
  Title: DEPS-1 promotes P granule assembly and RNA interference in C. elegans germ cells
  Description: P granules are germ-cell-specific cytoplasmic structures containing RNA and protein and required for proper germ cell development in C. elegans. A new P-granule-associated protein, DEPS-1, whose loss disrupts P granule structure and function was analysed in this study. Genome wide analysis of gene expression in deps-1 mutant germ lines identified additional targets of DEPS-1 regulation, many of which are also regulated by the RNAi factor RDE-3. Our studies suggest that DEPS-1 is a key component of the P granule assembly pathway and that its roles include promoting accumulation of some mRNAs, such as glh-1 and rde-4, and reducing accumulation of other mRNAs, perhaps by collaborating with RDE-3 to generate endogenous short interfering RNAs (endo-siRNAs). Keywords: Mutant analysis of deps-1 dissected C. elegans gonads
  Microarray_experiment: WBPaper00031477:deps-1_vs_N2_1
    WBPaper00031477:deps-1_vs_N2_2
    WBPaper00031477:N2_vs_deps-1_1
    WBPaper00031477:N2_vs_deps-1_2
  Species_in_analysis: Caenorhabditis elegans
  Reference: WBPaper00031477