WormBase Tree Display for Analysis: Microarray_Study.WBPaper00046083.ce.mr
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| Microarray_Study.WBPaper00046083.ce.mr | DB_info | Database | GEO | GSE53732 |
|---|---|---|---|---|
| Title | Conserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response | |||
| Description | Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the Caenorhabidits elegans innate immune response. Using whole genome transcriptional profiling, O-GlcNAc cycling mutants exhibited deregulation of unique stress- and immune-responsive genes as well as genes shared with the p38 MAPK/PMK-1 pathway. Moreover, genetic analysis showed that deletion of O-GlcNAc transferase (ogt-1) yielded animals hypersensitive to the human pathogen S. aureus but not to P. aeruginosa. Genetic interaction studies further revealed that nutrient-responsive OGT-1 acts through the conserved -catenin (BAR-1) pathway and in concert with p38 MAPK/PMK-1 to modulate the immune response to S. aureus. The participation of the nutrient sensor O-GlcNAc transferase in an immunity module conserved from C. elegans to humans reveals an unexplored nexus between nutrient availability and a pathogen-specific immune response. | |||
| Category | innate immune response | |||
| Microarray_experiment (36) | ||||
| Species_in_analysis | Caenorhabditis elegans | |||
| Reference | WBPaper00046083 |
