WormBase Tree Display for Analysis: Microarray_Study.WBPaper00059406.ce.mr
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| Microarray_Study.WBPaper00059406.ce.mr | DB_info | Database | GEO | GSE119917 |
|---|---|---|---|---|
| Title | Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C.elegans. | |||
| Description | Epigenetic states are metastable and changed throughout life, and their changes play a major role in the regulation of organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic stress resistance across tissues remain largely unknown. Here, we identify the intestine-to-germline communication of epigenetic states, which enhances stress resistance transgenerationally in C. elegans. We firstly show that the alteration in epigenetic states by deficiency of the histone H3K4me3 modifier ASH-2 in the intestine or germline increases organismal oxidative stress resistance, which is abrogated by knockdown of the H3K4 demethylase RBR-2 in the same tissue. Remarkably, the increase in stress resistance induced by ASH-2 deficiency in the intestine is abrogated by RBR-2 knockdown in the germline, suggesting the existence of inter-tissue transmission of epigenetic information from intestine to germline. Simultaneously, this intestine-to-germline communication in the parental generation transgenerationally provides the increase in stress resistance of the descendants for over two generations. Further analyses reveal that the inter-tissue communication requires the insulin/IGF-1 signaling effector DAF-16/FOXO in the intestine and is mediated, at least in part, by transcriptional regulation of F08F1.3, one of the intestinal ASH-2 target genes. These results unveil the novel intestine-to-germline communication of epigenetic information that provides the transgenerational regulation of organismal stress resistance. To further investigate the molecular mechanisms underlying intestine-to-germline communication, we sought the gene expression changes in the intestine ash-2 knockdown worms. | |||
| Category | RNA interference | |||
| Microarray_experiment | WBPaper00059406:N2_control | |||
| WBPaper00059406:N2_ash-2(RNAi) | ||||
| WBPaper00059406:VP303_control | ||||
| WBPaper00059406:VP303_ash-2(RNAi) | ||||
| WBPaper00059406:NR350_control | ||||
| WBPaper00059406:NR350_ash-2(RNAi) | ||||
| WBPaper00059406:TU3401_control | ||||
| WBPaper00059406:TU3401_ash-2(RNAi) | ||||
| Species_in_analysis | Caenorhabditis elegans | |||
| Reference | WBPaper00059406 |
