WormBase Tree Display for Gene: RGD:620314
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| RGD:620314 | Identity | Name | CGC_name | Ryr2 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Public_name | Ryr2 | |||||
| DB_info | Database | RGD | id | 620314 | ||
| AGR | cURI | RGD:620314 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSRNOG00000017060 | ||||
| UniProt | UniProt_AC | B0LPN4 | ||||
| Species | Rattus norvegicus | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00006801 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Hieranoid | ||||||
| Inparanoid | ||||||
| OMA | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| SonicParanoid | ||||||
| Structured_description | Automated_description | Enables ryanodine-sensitive calcium-release channel activity and scaffold protein binding activity. Involved in several processes, including metal ion transport; regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including A band; sarcolemma; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Colocalizes with Z disc. Used to study congestive heart failure. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 17beta-estradiol. | Inferred_automatically | AGR_import |
