WormBase Tree Display for Disease_model_annotation: WBDOannot00000724
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| WBDOannot00000724 | Disease_term | DOID:10652 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00035191 | |
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Modifier_gene | WBGene00006763 | |
| Modifier_association_type | condition_ameliorated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00040393 | ||
| Disease_model_description | A transgenic C. elegans model that expresses A-beta 1-42 in glutamatergic neurons, a neuronal subtype particularly vulnerable in Alzheimer's Disease. The eat-4 promoter, which regulates expression of the BNPI glutamate transporter targets A beta to the secretory pathway. Neuronal death increased from 50% at day 3 to 75% at day 7, establishing that this worm model exhibits age-dependent neurodegeneration; unc-26 (human SYNJ1 ortholog) is a genetic modifier whose expression in this strain has a neuroprotective effect. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 28 Oct 2019 00:00:00 |
