WormBase Tree Display for Disease_model_annotation: WBDOannot00001201
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WBDOannot00001201 | Disease_term | DOID:0050425 | |
---|---|---|---|
Disease_of_species | Homo sapiens | ||
Modeled_by | Disease_relevant_gene | WBGene00006796 | |
Association_type | is_implicated_in | ||
Evidence_code | GO_code | IMP | |
ECO_term | ECO:0007013 | ||
Genetic_sex | hermaphrodite | ||
Paper_evidence | WBPaper00060285 | ||
Disease_model_description | Human Meis1 (Myeloid Ecotropic viral Integration Site 1), a transcriptional regulator, is associated with not only the restless legs syndrome but also with self-reported symptoms of insomnia and sleep; Meis1 deficiency influences the dopaminergic system; in C. elegans the RNAi knockdown of unc-62, an ortholog of MEIS1, results in increased egg retention, diminished dop-3 function which is an ortholog of DRD2, and enhanced transcription of the ortholog of tyrosine hydroxylase, cat-2. | ||
Curator_confirmed | WBPerson324 | ||
Date_last_updated | 18 May 2022 00:00:00 |