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WormBase Tree Display for Disease_model_annotation: WBDOannot00001201

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Name Class

WBDOannot00001201Disease_termDOID:0050425
Disease_of_speciesHomo sapiens
Modeled_byDisease_relevant_geneWBGene00006796
Association_typeis_implicated_in
Evidence_codeGO_codeIMP
ECO_termECO:0007013
Genetic_sexhermaphrodite
Paper_evidenceWBPaper00060285
Disease_model_descriptionHuman Meis1 (Myeloid Ecotropic viral Integration Site 1), a transcriptional regulator, is associated with not only the restless legs syndrome but also with self-reported symptoms of insomnia and sleep; Meis1 deficiency influences the dopaminergic system; in C. elegans the RNAi knockdown of unc-62, an ortholog of MEIS1, results in increased egg retention, diminished dop-3 function which is an ortholog of DRD2, and enhanced transcription of the ortholog of tyrosine hydroxylase, cat-2.
Curator_confirmedWBPerson324
Date_last_updated18 May 2022 00:00:00