WormBase Tree Display for Gene: WBGene00000004
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| WBGene00000004 | Evidence | Author_evidence | Veljkovic E | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Verrey F | |||||||||
| SMap | S_parent | Sequence | F52H2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | aat-3 | |||||||
| Sequence_name | F52H2.2 | ||||||||
| Molecular_name | F52H2.2a | ||||||||
| F52H2.2a.1 | |||||||||
| CE28440 | |||||||||
| F52H2.2b | |||||||||
| CE50751 | |||||||||
| F52H2.2b.1 | |||||||||
| Other_name | CELE_F52H2.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | aat-3 | ||||||||
| DB_info | Database | AceView | gene | XD175 | |||||
| WormQTL | gene | WBGene00000004 | |||||||
| WormFlux | gene | WBGene00000004 | |||||||
| NDB | locus_tag | CELE_F52H2.2 | |||||||
| Panther | gene | CAEEL|WormBase=F52H2.2b|UniProtKB=A0A0K3AVL7 | |||||||
| family | PTHR11785 | ||||||||
| NCBI | gene | 180557 | |||||||
| RefSeq | protein | NM_001313422.5 | |||||||
| NM_076060.7 | |||||||||
| TrEMBL | UniProtAcc | O17395 | |||||||
| A0A0K3AVL7 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A0K3AVL7 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aat | ||||||||
| Allele (73) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | aat-3 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-3 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-3 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-3 localizes to the cell surface of oocytes, but when expressed alone, or with ATG-1, AAT-3 localizes intracellularly. | Paper_evidence | WBPaper00006408 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Mar 2006 00:00:00 | ||||||||
| Automated_description | Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); esophagitis; and glioblastoma. Is an ortholog of human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (25) | ||||||||
| Molecular_info | Corresponding_CDS | F52H2.2a | |||||||
| F52H2.2b | |||||||||
| Corresponding_transcript | F52H2.2a.1 | ||||||||
| F52H2.2b.1 | |||||||||
| Other_sequence (48) | |||||||||
| Associated_feature | WBsf647872 | ||||||||
| WBsf1004369 | |||||||||
| WBsf1004370 | |||||||||
| WBsf1022482 | |||||||||
| WBsf1022483 | |||||||||
| WBsf235397 | |||||||||
| WBsf235398 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00023484 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00112390 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032637 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048022 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015436 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1014672 | ||||||||
| Expr1030003 | |||||||||
| Expr1151840 | |||||||||
| Expr2009066 | |||||||||
| Expr2027302 | |||||||||
| Drives_construct | WBCnstr00037802 | ||||||||
| Construct_product | WBCnstr00037802 | ||||||||
| Antibody | WBAntibody00000718 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (155) | |||||||||
| Interaction (55) | |||||||||
| Map_info | Map | X | Position | -14.4112 | |||||
| Positive | Positive_clone | F52H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00006408 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042390 | |||||||||
| WBPaper00050950 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065331 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
