WormBase Tree Display for Gene: WBGene00000018
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| WBGene00000018 | SMap | S_parent | Sequence | M79 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | abl-1 | |||||||
| Sequence_name | M79.1 | ||||||||
| Molecular_name (24) | |||||||||
| Other_name | CELE_M79.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | abl-1 | ||||||||
| DB_info | Database (15) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | abl | ||||||||
| Allele (312) | |||||||||
| Legacy_information | [C.elegansII] NMK. Major transcript 4.4 kb; sequence (~400 aa) has 62% identity with oncogene v-abl in predicted kinase domain. [Goddard et al. 1986] | ||||||||
| Strain | WBStrain00002968 | ||||||||
| WBStrain00040670 | |||||||||
| WBStrain00040671 | |||||||||
| WBStrain00040673 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (65) | |||||||||
| Ortholog (35) | |||||||||
| Paralog (45) | |||||||||
| Structured_description | Concise_description | abl-1 encodes, by alternative splicing, three isoforms of a Src homology(SH) 2 and 3 domain-containing non-receptor tyrosine kinase orthologousto human ABL1 (OMIM:189980, mutated in chronic myeloid leukemia) andABL2 (OMIM:164690); ABL-1 inhibits germline apoptosis induced byradiation or by natural aging, but it has no effect on apoptosis inducedby starvation or by chemical mutagens (ethylnitrosourea,ethylmethanesulfonate, cisplatin, etoposide), or on constitutive('physiological') germline apoptosis; at the same time, ABL-1 isrequired for germline apoptosis induced by oxidative, osmotic orheat-shock stress, and is also required for pathogenesis by Shigellaflexneri infecting the intestine; ABL-1-inhibited apoptosis is confinedto a single gonad arm undergoing radiation, having no nonautonomouseffect on the unirradiated arm; abl-1 is expressed in the germline, inmost or all cells of early embryos, and in postembryonic pharynx, tailganglia and ventral nerve cord; abl-1(ok171) mutants are hypersensitiveto germline apoptosis and resistant to S. flexneri infection; bothabl-1(ok171) phenotypes are phenocopied by c-ABL inhibitors such asSTI-571 (Gleevec); ABL-1-inhibited apoptosis requires active CED-3 andEGL-1, inactive CED-9, and active AKT-1, CEP-1, CLK-1, HUS-1, and MRT-2;abl-1(ok171) has no effect on somatic apoptosis, and abl-1(ok171)mutants are generally normal; abl-1 transcripts are enriched in culturedunc-4::GFP neurons. | Paper_evidence | WBPaper00024301 | |||||
| WBPaper00025141 | |||||||||
| WBPaper00027170 | |||||||||
| WBPaper00027648 | |||||||||
| WBPaper00027729 | |||||||||
| WBPaper00029085 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including defense response to other organism; negative regulation of DNA damage response, signal transduction by p53 class mediator; and negative regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Expressed in Q cell; germ cell; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Is an ortholog of human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||
| DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
| DOID:8552 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
| DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
| DOID:0080630 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
| DOID:4914 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
| DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
| Molecular_info | Corresponding_CDS | M79.1a | |||||||
| M79.1b | |||||||||
| M79.1c | |||||||||
| M79.1d | |||||||||
| M79.1e | |||||||||
| M79.1f | |||||||||
| M79.1g | |||||||||
| M79.1h | |||||||||
| Corresponding_CDS_history | M79.1a:wp83 | ||||||||
| M79.1b:wp83 | |||||||||
| M79.1c:wp83 | |||||||||
| Corresponding_transcript | M79.1a.1 | ||||||||
| M79.1b.1 | |||||||||
| M79.1c.1 | |||||||||
| M79.1d.1 | |||||||||
| M79.1e.1 | |||||||||
| M79.1f.1 | |||||||||
| M79.1g.1 | |||||||||
| M79.1h.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Chronogram1126 | ||||||||
| Expr3045 | |||||||||
| Expr4844 | |||||||||
| Expr13648 | |||||||||
| Expr1013054 | |||||||||
| Expr1030006 | |||||||||
| Expr1154769 | |||||||||
| Expr2009093 | |||||||||
| Expr2027329 | |||||||||
| Drives_construct | WBCnstr00000775 | ||||||||
| WBCnstr00003474 | |||||||||
| WBCnstr00011096 | |||||||||
| WBCnstr00012272 | |||||||||
| WBCnstr00037793 | |||||||||
| Construct_product | WBCnstr00000775 | ||||||||
| WBCnstr00037793 | |||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction (130) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000066 | |||||||||
| WBbiopr:00000104 | |||||||||
| Map_info | Map | X | Position | 2.34106 | Error | 0.006695 | |||
| Positive | Positive_clone | M79 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| MC#191 | |||||||||
| Mapping_data | Multi_point | 4134 | |||||||
| 4652 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (48) | |||||||||
| Method | Gene |
