| WBGene00000018 | SMap | S_parent | Sequence | M79 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | abl-1 |
| | | Sequence_name | M79.1 |
| | | Molecular_name (24) |
| | | Other_name | CELE_M79.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | abl-1 |
| | DB_info | Database (15) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | abl |
| | Allele (312) |
| | Legacy_information | [C.elegansII] NMK. Major transcript 4.4 kb; sequence (~400 aa) has 62% identity with oncogene v-abl in predicted kinase domain. [Goddard et al. 1986] |
| | Strain | WBStrain00002968 |
| | | WBStrain00040670 |
| | | WBStrain00040671 |
| | | WBStrain00040673 |
| | RNASeq_FPKM (74) |
| | GO_annotation (65) |
| | Ortholog (35) |
| | Paralog (45) |
| | Structured_description | Concise_description | abl-1 encodes, by alternative splicing, three isoforms of a Src homology(SH) 2 and 3 domain-containing non-receptor tyrosine kinase orthologousto human ABL1 (OMIM:189980, mutated in chronic myeloid leukemia) andABL2 (OMIM:164690); ABL-1 inhibits germline apoptosis induced byradiation or by natural aging, but it has no effect on apoptosis inducedby starvation or by chemical mutagens (ethylnitrosourea,ethylmethanesulfonate, cisplatin, etoposide), or on constitutive('physiological') germline apoptosis; at the same time, ABL-1 isrequired for germline apoptosis induced by oxidative, osmotic orheat-shock stress, and is also required for pathogenesis by Shigellaflexneri infecting the intestine; ABL-1-inhibited apoptosis is confinedto a single gonad arm undergoing radiation, having no nonautonomouseffect on the unirradiated arm; abl-1 is expressed in the germline, inmost or all cells of early embryos, and in postembryonic pharynx, tailganglia and ventral nerve cord; abl-1(ok171) mutants are hypersensitiveto germline apoptosis and resistant to S. flexneri infection; bothabl-1(ok171) phenotypes are phenocopied by c-ABL inhibitors such asSTI-571 (Gleevec); ABL-1-inhibited apoptosis requires active CED-3 andEGL-1, inactive CED-9, and active AKT-1, CEP-1, CLK-1, HUS-1, and MRT-2;abl-1(ok171) has no effect on somatic apoptosis, and abl-1(ok171)mutants are generally normal; abl-1 transcripts are enriched in culturedunc-4::GFP neurons. | Paper_evidence | WBPaper00024301 |
| | | | | | WBPaper00025141 |
| | | | | | WBPaper00027170 |
| | | | | | WBPaper00027648 |
| | | | | | WBPaper00027729 |
| | | | | | WBPaper00029085 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 16 Apr 2007 00:00:00 |
| | | Automated_description | Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including defense response to other organism; negative regulation of DNA damage response, signal transduction by p53 class mediator; and negative regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Expressed in Q cell; germ cell; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Is an ortholog of human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| | | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| | | DOID:8552 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| | | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| | | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| | | DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| | | DOID:0080630 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| | | DOID:4914 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| | | DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) |
| Molecular_info | Corresponding_CDS | M79.1a |
| | | M79.1b |
| | | M79.1c |
| | | M79.1d |
| | | M79.1e |
| | | M79.1f |
| | | M79.1g |
| | | M79.1h |
| | Corresponding_CDS_history | M79.1a:wp83 |
| | | M79.1b:wp83 |
| | | M79.1c:wp83 |
| | Corresponding_transcript | M79.1a.1 |
| | | M79.1b.1 |
| | | M79.1c.1 |
| | | M79.1d.1 |
| | | M79.1e.1 |
| | | M79.1f.1 |
| | | M79.1g.1 |
| | | M79.1h.1 |
| | Other_sequence (21) |
| | Associated_feature | WBsf654354 |
| | | WBsf654356 |
| | | WBsf670984 |
| | | WBsf670985 |
| | | WBsf670986 |
| | | WBsf670987 |
| | | WBsf1006760 |
| | | WBsf1006761 |
| | | WBsf1006762 |
| | | WBsf1006763 |
| | | WBsf1006764 |
| | | WBsf1006765 |
| | | WBsf1006766 |
| | | WBsf1006767 |
| | | WBsf1006768 |
| | | WBsf1006769 |
| | | WBsf1023740 |
| | | WBsf1023741 |
| | | WBsf1023742 |
| | | WBsf1023743 |
| | | WBsf237880 |
| | | WBsf237881 |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern | Chronogram1126 |
| | | Expr3045 |
| | | Expr4844 |
| | | Expr13648 |
| | | Expr1013054 |
| | | Expr1030006 |
| | | Expr1154769 |
| | | Expr2009093 |
| | | Expr2027329 |
| | Drives_construct | WBCnstr00000775 |
| | | WBCnstr00003474 |
| | | WBCnstr00011096 |
| | | WBCnstr00012272 |
| | | WBCnstr00037793 |
| | Construct_product | WBCnstr00000775 |
| | | WBCnstr00037793 |
| | Microarray_results (32) |
| | Expression_cluster | WBPaper00006195:azacoprostane_downregulated |
| | | WBPaper00029359_1142 |
| | | WBPaper00029359_1217 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1604 |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00040209:B.thuringiensis_upregulated_MY15 |
| | | WBPaper00040209:B.thuringiensis_upregulated_N2 |
| | | WBPaper00040731:Static_Magnetic_Field_upregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049217:TCER-1_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056855:his-72(uge40)_downregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:pm6 |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061466:nath-10(icb99)_downregulated |
| | | WBPaper00061527:chd-7_16664-jmjd-3.1 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273) |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030985:Serratia_marcesens_downregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (130) |
| | WBProcess | WBbiopr:00000014 |
| | | WBbiopr:00000066 |
| | | WBbiopr:00000104 |
| Map_info | Map | X | Position | 2.34106 | Error | 0.006695 |
| | Positive | Positive_clone | M79 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | MC#191 |
| | Mapping_data | Multi_point | 4134 |
| | | | 4652 |
| | Pseudo_map_position |
| Reference (48) |
| Method | Gene |
