WormBase Tree Display for Gene: WBGene00000018

WBGene00000018 SMap: S_parent: Sequence: M79
  Identity: Version: 1
    Name: CGC_name: abl-1
      Sequence_name: M79.1
      Molecular_name (24)
      Other_name: CELE_M79.1 Accession_evidence: NDB BX284606
      Public_name: abl-1
    DB_info: Database (15)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: abl
    Allele (312)
    Legacy_information: [C.elegansII] NMK. Major transcript 4.4 kb; sequence (~400 aa) has 62% identity with oncogene v-abl in predicted kinase domain. [Goddard et al. 1986]
    Strain: WBStrain00002968
      WBStrain00040670
      WBStrain00040671
      WBStrain00040673
    RNASeq_FPKM (74)
    GO_annotation (65)
    Ortholog (35)
    Paralog (45)
    Structured_description: Concise_description: abl-1 encodes, by alternative splicing, three isoforms of a Src homology(SH) 2 and 3 domain-containing non-receptor tyrosine kinase orthologousto human ABL1 (OMIM:189980, mutated in chronic myeloid leukemia) andABL2 (OMIM:164690); ABL-1 inhibits germline apoptosis induced byradiation or by natural aging, but it has no effect on apoptosis inducedby starvation or by chemical mutagens (ethylnitrosourea,ethylmethanesulfonate, cisplatin, etoposide), or on constitutive('physiological') germline apoptosis; at the same time, ABL-1 isrequired for germline apoptosis induced by oxidative, osmotic orheat-shock stress, and is also required for pathogenesis by Shigellaflexneri infecting the intestine; ABL-1-inhibited apoptosis is confinedto a single gonad arm undergoing radiation, having no nonautonomouseffect on the unirradiated arm; abl-1 is expressed in the germline, inmost or all cells of early embryos, and in postembryonic pharynx, tailganglia and ventral nerve cord; abl-1(ok171) mutants are hypersensitiveto germline apoptosis and resistant to S. flexneri infection; bothabl-1(ok171) phenotypes are phenocopied by c-ABL inhibitors such asSTI-571 (Gleevec); ABL-1-inhibited apoptosis requires active CED-3 andEGL-1, inactive CED-9, and active AKT-1, CEP-1, CLK-1, HUS-1, and MRT-2;abl-1(ok171) has no effect on somatic apoptosis, and abl-1(ok171)mutants are generally normal; abl-1 transcripts are enriched in culturedunc-4::GFP neurons. Paper_evidence: WBPaper00024301
            WBPaper00025141
            WBPaper00027170
            WBPaper00027648
            WBPaper00027729
            WBPaper00029085
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 16 Apr 2007 00:00:00
      Automated_description: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including defense response to other organism; negative regulation of DNA damage response, signal transduction by p53 class mediator; and negative regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Expressed in Q cell; germ cell; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Is an ortholog of human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:8552 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:0080630 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:4914 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
  Molecular_info: Corresponding_CDS: M79.1a
      M79.1b
      M79.1c
      M79.1d
      M79.1e
      M79.1f
      M79.1g
      M79.1h
    Corresponding_CDS_history: M79.1a:wp83
      M79.1b:wp83
      M79.1c:wp83
    Corresponding_transcript: M79.1a.1
      M79.1b.1
      M79.1c.1
      M79.1d.1
      M79.1e.1
      M79.1f.1
      M79.1g.1
      M79.1h.1
    Other_sequence (21)
    Associated_feature: WBsf654354
      WBsf654356
      WBsf670984
      WBsf670985
      WBsf670986
      WBsf670987
      WBsf1006760
      WBsf1006761
      WBsf1006762
      WBsf1006763
      WBsf1006764
      WBsf1006765
      WBsf1006766
      WBsf1006767
      WBsf1006768
      WBsf1006769
      WBsf1023740
      WBsf1023741
      WBsf1023742
      WBsf1023743
      WBsf237880
      WBsf237881
  Experimental_info: RNAi_result (16)
    Expr_pattern: Chronogram1126
      Expr3045
      Expr4844
      Expr13648
      Expr1013054
      Expr1030006
      Expr1154769
      Expr2009093
      Expr2027329
    Drives_construct: WBCnstr00000775
      WBCnstr00003474
      WBCnstr00011096
      WBCnstr00012272
      WBCnstr00037793
    Construct_product: WBCnstr00000775
      WBCnstr00037793
    Microarray_results (32)
    Expression_cluster (112)
    Interaction: WBInteraction000004562
      WBInteraction000004563
      WBInteraction000004606
      WBInteraction000004607
      WBInteraction000004627
      WBInteraction000004628
      WBInteraction000032603
      WBInteraction000033015
      WBInteraction000033016
      WBInteraction000033083
      WBInteraction000033215
      WBInteraction000033339
      WBInteraction000033446
      WBInteraction000033475
      WBInteraction000033968
      WBInteraction000033969
      WBInteraction000033970
      WBInteraction000034090
      WBInteraction000034244
      WBInteraction000034353
      WBInteraction000034383
      WBInteraction000034665
      WBInteraction000034813
      WBInteraction000034814
      WBInteraction000035358
      WBInteraction000035359
      WBInteraction000037240
      WBInteraction000038218
      WBInteraction000041841
      WBInteraction000114659
      WBInteraction000114660
      WBInteraction000114661
      WBInteraction000114662
      WBInteraction000114668
      WBInteraction000114669
      WBInteraction000136863
      WBInteraction000139065
      WBInteraction000139071
      WBInteraction000142020
      WBInteraction000161799
      WBInteraction000166971
      WBInteraction000192585
      WBInteraction000207051
      WBInteraction000210021
      WBInteraction000213942
      WBInteraction000214250
      WBInteraction000247370
      WBInteraction000288546
      WBInteraction000299366
      WBInteraction000335548
      WBInteraction000347434
      WBInteraction000356713
      WBInteraction000356960
      WBInteraction000389836
      WBInteraction000404663
      WBInteraction000404893
      WBInteraction000407687
      WBInteraction000408692
      WBInteraction000411620
      WBInteraction000431131
      WBInteraction000441318
      WBInteraction000458966
      WBInteraction000523672
      WBInteraction000523673
      WBInteraction000523674
      WBInteraction000523675
      WBInteraction000523676
      WBInteraction000523677
      WBInteraction000523678
      WBInteraction000523679
      WBInteraction000523680
      WBInteraction000523681
      WBInteraction000523682
      WBInteraction000523683
      WBInteraction000523684
      WBInteraction000523685
      WBInteraction000523686
      WBInteraction000523687
      WBInteraction000523688
      WBInteraction000523689
      WBInteraction000538791
      WBInteraction000538845
      WBInteraction000540663
      WBInteraction000542940
      WBInteraction000545876
      WBInteraction000545877
      WBInteraction000545878
      WBInteraction000545879
      WBInteraction000545880
      WBInteraction000545881
      WBInteraction000545882
      WBInteraction000545883
      WBInteraction000545884
      WBInteraction000545885
      WBInteraction000545886
      WBInteraction000545887
      WBInteraction000545888
      WBInteraction000545889
      WBInteraction000545890
      WBInteraction000545891
      WBInteraction000545892
      WBInteraction000545893
      WBInteraction000545894
      WBInteraction000545895
      WBInteraction000545896
      WBInteraction000545897
      WBInteraction000545898
      WBInteraction000545899
      WBInteraction000545900
      WBInteraction000545901
      WBInteraction000545902
      WBInteraction000545903
      WBInteraction000545904
      WBInteraction000545905
      WBInteraction000545906
      WBInteraction000545907
      WBInteraction000545908
      WBInteraction000545909
      WBInteraction000545910
      WBInteraction000545911
      WBInteraction000545912
      WBInteraction000545913
      WBInteraction000547420
      WBInteraction000547535
      WBInteraction000547614
      WBInteraction000569157
      WBInteraction000569159
      WBInteraction000578609
      WBInteraction000582175
      WBInteraction000584313
    WBProcess: WBbiopr:00000014
      WBbiopr:00000066
      WBbiopr:00000104
  Map_info: Map: X Position: 2.34106 Error: 0.006695
    Positive: Positive_clone: M79 Inferred_automatically: From sequence, transcript, pseudogene data
        MC#191
    Mapping_data: Multi_point: 4134
        4652
    Pseudo_map_position
  Reference (48)
  Method: Gene