WormBase Tree Display for Gene: WBGene00000035
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WBGene00000035 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | ace-1 | Person_evidence | WBPerson1417 | |||||
WBPerson36909 | |||||||||
WBPerson7188 | |||||||||
Sequence_name | W09B12.1 | ||||||||
Molecular_name (3) | |||||||||
Other_name | ACE1 | Accession_evidence | EMBL | X75331 | |||||
cest-23 | |||||||||
CELE_W09B12.1 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | ace-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | ace-1 | ||||
Other_name | cest-23 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | ace | ||||||||
Reference_allele | WBVar00095133 | ||||||||
Allele (103) | |||||||||
Legacy_information | p1000 : class A acetylcholinesterase reduced 100%; no behavioral phenotype alone (ES1 ME3) but ace-2;ace-1 is uncoordinated (hypercontracted) and ace-2;ace-3;ace-1 is L1 lethal. NA7. | ||||||||
See also e1572 | |||||||||
[C.elegansII] p1000 : class A acetylcholinesterase reduced 100%; no behavioral phenotype alone (ES1 ME3) but ace-2;ace-1 is uncoordinated (hypercontracted) and ace-2;ace-3;ace-1 is L1 lethal. Mosaic focus in muscle. OA6: e1572 etc.Cloned: sequence predicts 609 aa, 37% identity with Torpedo acetylcholinesterase. p1000 is W99op. [Herman and Kari 1985; Arpagaus et al. 1994; FF] | |||||||||
Strain | WBStrain00024338 | ||||||||
WBStrain00030800 | |||||||||
WBStrain00035826 | |||||||||
WBStrain00040622 | |||||||||
WBStrain00007852 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (31) | |||||||||
Ortholog (38) | |||||||||
Paralog (38) | |||||||||
Structured_description | Concise_description | ace-1 encodes a class A acetylcholinesterase that functions redundantly with ACE-2 with respect to total class A acetylcholinesterase activity, and that genetically interacts with ace-2 and ace-3; ace-1 is expressed in the body wall muscle, sphincter muscle, head neurons, a few pharyngeal muscle cells, and the diagonal and spicule muscles of the male. | Paper_evidence | WBPaper00000514 | |||||
WBPaper00000795 | |||||||||
WBPaper00002110 | |||||||||
WBPaper00003620 | |||||||||
WBPaper00004251 | |||||||||
WBPaper00004932 | |||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson480 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables acetylcholinesterase activity and identical protein binding activity. Involved in acetylcholine catabolic process and regulation of locomotion. Located in extracellular space. Expressed in CEP; M cell; OLL; body wall musculature; and non-striated muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); and autoimmune disease (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (19) | ||||||||
Molecular_info | Corresponding_CDS | W09B12.1 | |||||||
Corresponding_transcript | W09B12.1.1 | ||||||||
Other_sequence (25) | |||||||||
Associated_feature | WBsf648845 | ||||||||
WBsf663688 | |||||||||
WBsf979005 | |||||||||
WBsf1008508 | |||||||||
WBsf1008509 | |||||||||
WBsf1008510 | |||||||||
WBsf236851 | |||||||||
Experimental_info | RNAi_result | WBRNAi00075453 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089181 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00019735 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00030254 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00055010 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr1222 | ||||||||
Expr1015117 | |||||||||
Expr1030015 | |||||||||
Expr1158543 | |||||||||
Expr2009142 | |||||||||
Expr2027379 | |||||||||
Drives_construct | WBCnstr00008263 | ||||||||
WBCnstr00008264 | |||||||||
WBCnstr00008265 | |||||||||
WBCnstr00008267 | |||||||||
WBCnstr00008268 | |||||||||
WBCnstr00010160 | |||||||||
WBCnstr00018564 | |||||||||
WBCnstr00037779 | |||||||||
Construct_product | WBCnstr00008263 | ||||||||
WBCnstr00008264 | |||||||||
WBCnstr00008265 | |||||||||
WBCnstr00008266 | |||||||||
WBCnstr00008268 | |||||||||
WBCnstr00010160 | |||||||||
WBCnstr00037779 | |||||||||
Regulate_expr_cluster | WBPaper00044452:ace_1_ace-2_downregulated | ||||||||
WBPaper00044452:ace_1_ace-2_upregulated | |||||||||
Microarray_results (24) | |||||||||
Expression_cluster (119) | |||||||||
Interaction (48) | |||||||||
Anatomy_function | WBbtf0036 | ||||||||
WBbtf0037 | |||||||||
WBbtf0038 | |||||||||
WBbtf1031 | |||||||||
WBbtf1032 | |||||||||
WBbtf1033 | |||||||||
Map_info | Map | X | Position | 23.9071 | Error | 0.00351 | |||
Well_ordered | |||||||||
Positive | Positive_clone | W09B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 3682 | |||||||
Multi_point | 195 | ||||||||
196 | |||||||||
4958 | |||||||||
Pos_neg_data (15) | |||||||||
Landmark_gene | |||||||||
Reference (92) | |||||||||
Method | Gene |