WormBase Tree Display for Gene: WBGene00000046

WBGene00000046 SMap: S_parent: Sequence: T09A5
  Identity: Version: 1
    Name: CGC_name: acr-7 Person_evidence: WBPerson1430
      Sequence_name: T09A5.3
      Molecular_name: T09A5.3
        T09A5.3.1
        CE28078
      Other_name: CELE_T09A5.3 Accession_evidence: NDB BX284602
      Public_name: acr-7
    DB_info: Database: AceView gene 2I136
        WormQTL gene WBGene00000046
        WormFlux gene WBGene00000046
        NDB locus_tag CELE_T09A5.3
        Panther gene CAEEL|WormBase=WBGene00000046|UniProtKB=P45963
          family PTHR18945
        NCBI gene 174262
        RefSeq protein NM_063246.5
        SwissProt UniProtAcc P45963
        UniProt_GCRP UniProtAcc P45963
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acr
    Allele (62)
    Strain: WBStrain00035703
      WBStrain00007571
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (43)
    Paralog (100)
    Structured_description: Concise_description: acr-7 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-7 is expressed pharyngeal muscle and in tail neurons distal to the anus, and is a member of the ACR-16-like group of nAChR subunits. Paper_evidence: WBPaper00003425
            WBPaper00005427
            WBPaper00005594
            WBPaper00018318
          Curator_confirmed: WBPerson1843
            WBPerson480
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:12217 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:7474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
  Molecular_info: Corresponding_CDS: T09A5.3
    Corresponding_CDS_history: T09A5.3:wp52
    Corresponding_transcript: T09A5.3.1
    Other_sequence: MI00090
      Tcol_isotig22583
      JI252964.1
      JI252559.1
    Associated_feature: WBsf650274
      WBsf665743
      WBsf717716
      WBsf223401
  Experimental_info: RNAi_result: WBRNAi00035374 Inferred_automatically: RNAi_primary
      WBRNAi00018488 Inferred_automatically: RNAi_primary
      WBRNAi00102754 Inferred_automatically: RNAi_primary
      WBRNAi00052920 Inferred_automatically: RNAi_primary
      WBRNAi00052919 Inferred_automatically: RNAi_primary
      WBRNAi00066386 Inferred_automatically: RNAi_primary
      WBRNAi00018487 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr10770
      Expr1013772
      Expr1156523
      Expr2009196
      Expr2027434
    Drives_construct: WBCnstr00017724
      WBCnstr00037771
    Construct_product: WBCnstr00017724
      WBCnstr00037771
    Microarray_results (19)
    Expression_cluster (72)
    Interaction: WBInteraction000353737
  Map_info: Map: II Position: 0.579639 Error: 0.001478
    Positive: Positive_clone: T09A5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4137
        4222
    Pseudo_map_position
  Reference (19)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene