WormBase Tree Display for Gene: WBGene00000048

WBGene00000048 SMap: S_parent: Sequence: C40C9
  Identity: Version: 1
    Name: CGC_name: acr-9 Person_evidence: WBPerson1430
      Sequence_name: C40C9.2
      Molecular_name: C40C9.2
        C40C9.2.1
        CE37330
      Other_name: CELE_C40C9.2 Accession_evidence: NDB BX284606
      Public_name: acr-9
    DB_info: Database: AceView gene XO262
        WormQTL gene WBGene00000048
        WormFlux gene WBGene00000048
        NDB locus_tag CELE_C40C9.2
        Panther gene CAEEL|WormBase=WBGene00000048|UniProtKB=Q18556
          family PTHR18945
        NCBI gene 191597
        RefSeq protein NM_077884.5
        TrEMBL UniProtAcc Q18556
        UniProt_GCRP UniProtAcc Q18556
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acr
    Allele (86)
    Strain: WBStrain00035950
      WBStrain00035014
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (33)
    Paralog (100)
    Structured_description: Concise_description: acr-9 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors. Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:12217 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:7474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
  Molecular_info: Corresponding_CDS: C40C9.2
    Corresponding_CDS_history: C40C9.2:wp121
      C40C9.2:wp131
    Corresponding_transcript: C40C9.2.1
    Other_sequence (20)
    Associated_feature: WBsf654536
      WBsf654537
      WBsf1007676
      WBsf238157
  Experimental_info: RNAi_result: WBRNAi00011810 Inferred_automatically: RNAi_primary
      WBRNAi00042249 Inferred_automatically: RNAi_primary
      WBRNAi00029703 Inferred_automatically: RNAi_primary
      WBRNAi00066391 Inferred_automatically: RNAi_primary
      WBRNAi00102758 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1010409
      Expr1146240
      Expr1200297
      Expr2009198
      Expr2027436
    Drives_construct: WBCnstr00037769
    Construct_product: WBCnstr00037769
    Microarray_results (19)
    Expression_cluster (112)
    Interaction: WBInteraction000149612
      WBInteraction000239096
      WBInteraction000304002
      WBInteraction000518503
  Map_info: Map: X Position: 14.0194 Error: 0.038412
    Positive: Positive_clone: C40C9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5297
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene