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WormBase Tree Display for Gene: WBGene00000053

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Name Class

WBGene00000053SMapS_parentSequenceT05C12
IdentityVersion1
NameCGC_nameacr-14Person_evidenceWBPerson1430
Sequence_nameT05C12.2
Molecular_nameT05C12.2
T05C12.2.1
CE25099
Other_nameCELE_T05C12.2Accession_evidenceNDBBX284602
Public_nameacr-14
DB_infoDatabaseAceViewgene2I462
WormQTLgeneWBGene00000053
WormFluxgeneWBGene00000053
NDBlocus_tagCELE_T05C12.2
PanthergeneCAEEL|WormBase=WBGene00000053|UniProtKB=Q22224
familyPTHR18945
NCBIgene191601
RefSeqproteinNM_063315.3
TrEMBLUniProtAccQ22224
UniProt_GCRPUniProtAccQ22224
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:19WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classacr
Allele (30)
StrainWBStrain00031836
RNASeq_FPKM (74)
GO_annotation (28)
Ortholog (36)
Paralog (100)
Structured_descriptionConcise_descriptionacr-14 encodes a protein that contains neurotransmitter-gated ion-channel ligand-binding and transmembrane domains.Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:3748Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:8778Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:3083Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:12217Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:8577Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:1324Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:7474Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:5419Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
Molecular_infoCorresponding_CDST05C12.2
Corresponding_transcriptT05C12.2.1
Other_sequenceJI180092.1
Associated_featureWBsf223455
WBsf223456
Experimental_infoRNAi_resultWBRNAi00066388Inferred_automaticallyRNAi_primary
WBRNAi00097922Inferred_automaticallyRNAi_primary
WBRNAi00052489Inferred_automaticallyRNAi_primary
WBRNAi00018218Inferred_automaticallyRNAi_primary
WBRNAi00078345Inferred_automaticallyRNAi_primary
WBRNAi00035191Inferred_automaticallyRNAi_primary
Expr_patternChronogram1906
Expr4858
Expr8203
Expr10607
Expr13428
Expr1018728
Expr1156115
Expr2009181
Expr2027420
Drives_construct (11)
Construct_productWBCnstr00016680
WBCnstr00037766
Microarray_results (20)
Expression_clusterWBPaper00024970:GABAergic_neuron_specific
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:all-neurons_larva_SelectivelyEnriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_CoreEnriched
WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_larva_enriched
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00048988:neuron_expressed
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00053302:alovudine_72h_regulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059763:neuron_expressed
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060703:nas-38(ok3407)_upregulated
WBPaper00061340:AMso
WBPaper00061340:AVA
WBPaper00061340:AVE
WBPaper00061340:AVJ
WBPaper00061340:DA
WBPaper00061340:DA_DB
WBPaper00061340:DD
WBPaper00061340:DVA
WBPaper00061340:Parents_of_Y_DA6_DA7_DA9
WBPaper00061340:Pharyngeal_intestinal_valve
WBPaper00061340:SMB
WBPaper00061341:28C_48h_upregulated
WBPaper00061527:ckr-1-T09B9.3
WBPaper00061651:AS_enriched
WBPaper00061651:SAB_enriched
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
WBPaper00064716:paraquat_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065841:6_0
WBPaper00065841:6_2
WBPaper00065841:10_0
WBPaper00065841:14_0
WBPaper00065841:14_1
WBPaper00065841:14_2
WBPaper00065841:50_0
WBPaper00065841:56_0
WBPaper00065841:61_0
WBPaper00065841:98_0
WBPaper00065841:117_0
WBPaper00065841:119_0
WBPaper00065841:132_0
WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
WBPaper00005124:testosterone_10-9M_regulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Larval_A_Class
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031252:AIN-1_IP_enriched
WBPaper00035588:alg-1(-)_upregulated
WBPaper00036123:Atrazine_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00042548:miRISC_enriched
WBPaper00045673:colistin_upregulated
WBPaper00056330:mrps-5(RNAi)_upregulated
Interaction (28)
Map_infoMapIIPosition0.742235Error0.001179
PositivePositive_cloneT05C12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4965
4646
5546
Pseudo_map_position
Reference (26)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene