[Jim Thomas] Defecation defective, slightly constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) missing in five of six defecation cycles, adult males unaffected and mate well.
See also ad418, ad696, sa5
[Iwasaki K] aBoc and Exp defective.
[C.elegansII] ad418 : defecation defective, slightly constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) missing in five of six defecation cycles, adult males unaffected and mate well. Interactions (Daf-c and Eat) with unc-31. OA3: sa5, ad696, n2166. Cloned: cosmid C02H7 [Thomas 1990; JT, DA]
aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584); AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively; AEX-3 is also required for egg laying and locomotion; AEX-3 is expressed in nearly all neurons.
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of transport. Predicted to be located in cytosol. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human MADD (MAP kinase activating death domain).
Interacting_genes '[Jim Thomas] Unc-31: Synthetic phenotypes with all tested unc-31 alleles, Daf-c and pharyngeal pumping defective (not seen with aex-1, 2, 4, 5, or 6 mutations).'
Positive_clone C02H7 is based on stable transformation rescue