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WormBase Tree Display for Gene: WBGene00000086

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Name Class

WBGene00000086SMapS_parentSequenceC02H7
IdentityVersion1
NameCGC_nameaex-3Person_evidenceWBPerson655
Sequence_nameC02H7.3
Molecular_nameC02H7.3a
C02H7.3a.1
CE16806
C02H7.3b
CE30850
C02H7.3b.1
Other_nameCELE_C02H7.3Accession_evidenceNDBBX284606
Public_nameaex-3
DB_infoDatabaseAceViewgeneXB370
WormQTLgeneWBGene00000086
WormFluxgeneWBGene00000086
NDBlocus_tagCELE_C02H7.3
PanthergeneCAEEL|WormBase=WBGene00000086|UniProtKB=O02626
familyPTHR13008
NCBIgene180420
RefSeqproteinNM_001029171.7
NM_171618.6
SwissProtUniProtAccO02626
TREEFAMTREEFAM_IDTF318583
UniProt_GCRPUniProtAccO02626
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classaex
Allele (129)
Legacy_information[Jim Thomas] Defecation defective, slightly constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) missing in five of six defecation cycles, adult males unaffected and mate well.
See also ad418, ad696, sa5
[Iwasaki K] aBoc and Exp defective.
[C.elegansII] ad418 : defecation defective, slightly constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) missing in five of six defecation cycles, adult males unaffected and mate well. Interactions (Daf-c and Eat) with unc-31. OA3: sa5, ad696, n2166. Cloned: cosmid C02H7 [Thomas 1990; JT, DA]
Strain (11)
RNASeq_FPKM (74)
GO_annotation (25)
OrthologWBGene00060240Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00029981Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00139092Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00119605Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00156824Caenorhabditis brenneriFrom_analysisTreeFam
WBGene00123141Caenorhabditis japonicaFrom_analysisTreeFam
WBGene00051714Caenorhabditis remaneiFrom_analysisTreeFam
WBGene00222188Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g3547Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g2881Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g1900Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g13406Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g20752Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g11481Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g16584Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g16585Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g18673Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g9810Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g4245Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00309.g8971Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-aex-3Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g15636Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00693.g14472Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_03210Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_022196Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g12812Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g7137Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0017600Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g18320Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00240823Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00105339Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00268172Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00294572Trichuris murisFrom_analysisWormBase-Compara
WBGene00299937Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0030613Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-030131-8076Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:6766Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2444672Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:619922Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ParalogWBGene00003477Caenorhabditis elegansFrom_analysisTreeFam
Structured_descriptionConcise_descriptionaex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584); AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively; AEX-3 is also required for egg laying and locomotion; AEX-3 is expressed in nearly all neurons.Paper_evidenceWBPaper00001256
WBPaper00002776
WBPaper00004331
Curator_confirmedWBPerson48
WBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of transport. Predicted to be located in cytosol. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human MADD (MAP kinase activating death domain).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00031669
Curator_confirmedWBPerson324
Date_last_updated06 Jun 2019 00:00:00
Models_disease_assertedWBDOannot00000711
Molecular_infoCorresponding_CDSC02H7.3a
C02H7.3b
Corresponding_transcriptC02H7.3a.1
C02H7.3b.1
Other_sequence (26)
Associated_featureWBsf1003855
WBsf236956
WBsf236957
WBsf236958
Experimental_infoRNAi_result (21)
Expr_patternChronogram705
Expr335
Expr3831
Expr5117
Expr1021104
Expr1030040
Expr1143577
Expr2009248
Expr2027485
Drives_construct (24)
Construct_productWBCnstr00011346
WBCnstr00011682
WBCnstr00022894
WBCnstr00037742
Microarray_results (29)
Expression_cluster (159)
Interaction (36)
WBProcessWBbiopr:00000001
WBbiopr:00000010
Map_infoMapXPosition-19.504Error0.000746
Well_ordered
PositivePositive_cloneC02H7Person_evidenceWBPerson287
Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeNegative_cloneM02A10Person_evidenceWBPerson287
R04F4Person_evidenceWBPerson287
Mapping_data2_point4467
4570
Multi_point1548
1549
1586
Reference (75)
RemarkInteracting_genes '[Jim Thomas] Unc-31: Synthetic phenotypes with all tested unc-31 alleles, Daf-c and pharyngeal pumping defective (not seen with aex-1, 2, 4, 5, or 6 mutations).'
Positive_clone C02H7 is based on stable transformation rescuePerson_evidenceWBPerson287
MethodGene