WormBase Tree Display for Gene: WBGene00000099
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| WBGene00000099 | SMap | S_parent | Sequence | B0207 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | air-2 | Person_evidence | WBPerson205 | |||||
| Sequence_name | B0207.4 | ||||||||
| Molecular_name | B0207.4 | ||||||||
| B0207.4.1 | |||||||||
| CE24761 | |||||||||
| B0207.4.2 | |||||||||
| Other_name | let-603 | ||||||||
| stu-7 | |||||||||
| cyk-6 | |||||||||
| CELE_B0207.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | air-2 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | air | ||||||||
| Allele (19) | |||||||||
| Legacy_information | [Hodgkin JA] e2631 hermaphrodites are long, uncoordinated and sterile, usually with a conspicuous constriction in the mid-region of the body. Males grow poorly, male tail very abnormal, ME0. | ||||||||
| [McDowall JS] Sterile adult | |||||||||
| [C.elegansII] h289 : sterile adult (gonad tumorous mass). OA3: h408, h437, h812 (sterile adults). Cloned: partial cosmid rescue (C32E7); rescued to Mel. [KR] | |||||||||
| [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. cytokinesis defects | |||||||||
| Strain | WBStrain00023752 | ||||||||
| WBStrain00035642 | |||||||||
| WBStrain00004633 | |||||||||
| WBStrain00007296 | |||||||||
| WBStrain00007300 | |||||||||
| WBStrain00034749 | |||||||||
| WBStrain00051600 | |||||||||
| WBStrain00051601 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (65) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00000098 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | air-2 encodes an aurora/Ipl1-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 i modified in vitro by the GEI-17 E3 SUMO ligase; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. | Paper_evidence (12) | ||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson363 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Jun 2015 00:00:00 | ||||||||
| Automated_description | Enables ATPase binding activity; kinesin binding activity; and protein kinase activity. Involved in several processes, including chromosome condensation; regulation of actomyosin contractile ring contraction; and spindle midzone assembly. Located in condensed nuclear chromosome and spindle midzone. Expressed in oocyte and sperm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human AURKB (aurora kinase B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||||
| DOID:3008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||||
| DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||||
| DOID:0070183 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11391) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||||
| DOID:8634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393) | ||||||
| DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||||
| DOID:363 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||||
| Molecular_info | Corresponding_CDS | B0207.4 | |||||||
| Corresponding_transcript | B0207.4.1 | ||||||||
| B0207.4.2 | |||||||||
| Other_sequence (54) | |||||||||
| Associated_feature | WBsf217728 | ||||||||
| WBsf217729 | |||||||||
| Experimental_info | RNAi_result (63) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00037734 | ||||||||
| Construct_product | WBCnstr00000897 | ||||||||
| WBCnstr00005318 | |||||||||
| WBCnstr00005560 | |||||||||
| WBCnstr00014917 | |||||||||
| WBCnstr00017655 | |||||||||
| WBCnstr00021506 | |||||||||
| WBCnstr00037734 | |||||||||
| Antibody | WBAntibody00000198 | ||||||||
| WBAntibody00000511 | |||||||||
| WBAntibody00001492 | |||||||||
| WBAntibody00002053 | |||||||||
| WBAntibody00002354 | |||||||||
| WBAntibody00002454 | |||||||||
| WBAntibody00002607 | |||||||||
| WBAntibody00002722 | |||||||||
| WBAntibody00002782 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (167) | |||||||||
| Interaction (256) | |||||||||
| Map_info | Map | I | Position | 0.482005 | Error | 0.002155 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | B0207 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| C32E7 | |||||||||
| Negative | Outside_rearr | hDf29 | |||||||
| Negative_clone | C03E6 | ||||||||
| C04F1 | |||||||||
| C07F10 | |||||||||
| C30B6 | |||||||||
| C53A11 | |||||||||
| Mapping_data | 2_point | 5225 | |||||||
| 5226 | |||||||||
| Multi_point | 3520 | ||||||||
| 3865 | |||||||||
| 4380 | |||||||||
| 4601 | |||||||||
| Pos_neg_data (12) | |||||||||
| Reference (120) | |||||||||
| Remark | [McDowall JS] Extrachromosomal array containing single cosmid generated, then manipulated genetically. Partial rescue: normally sterile adult with tumorous mass, develops to tumorless egg-laying adult, eggs do not develop or hatch. | ||||||||
| testing swap around with sup-40, from 0.435 to 0.575 | |||||||||
| same as cyk-6 according to cgc4544 and email 114. | |||||||||
| same as air-2 according to cgc4544 and email 114. | |||||||||
| old_name cyk-6 becomes new_name air-2 from [Woollard A, Hodgkin JA, Schumacher J]. | |||||||||
| old_names let-603 and stu-7 had previously been identitifed with air-2. | |||||||||
| Method | Gene |
